Medicine for treating thrombocytopenia and anemia and its prepn process and quality control method

A quality control method and platelet technology, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as inaccurate measurement results.

Active Publication Date: 2007-03-21
JILIN AODONG GRP LIYUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] This requires us to produce high-quality products, but the original quality control method is to use dual-wavelength thin-layer chromatography to determine the content of astragaloside IV in this product, and the determination results are not particularly accurate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1 Preparation of medicament oral liquid of the present invention

[0086] It is made from the following raw materials:

[0087] Donkey-hide gelatin 5g, astragalus 200g, angelica 150g, jujube 100g, antler glue 15g.

[0088] 1) extract volatile oil from Angelica sinensis by distillation, and set aside;

[0089] 2) Take the dregs of angelica, astragalus and jujube, add water and decoct twice for 3 and 2 hours respectively, add 5 times and 3 times the amount of water respectively, filter, combine the filtrates, and concentrate to a relative density of 1.23-1.28 (measured at 20°C) clear ointment, add ethanol to make the alcohol concentration reach 65%, fully stir, stand still for 24 hours, filter, reclaim ethanol from the filtrate, and obtain medicinal material extracts such as Angelica sinensis. Add water to the extract of angelica and other medicinal materials to 250ml, add angelica volatile oil, mix well, and set aside;

[0090] 3) Add appropriate amount of ...

Embodiment 2

[0092] Embodiment 2 Preparation of pharmaceutical capsules of the present invention

[0093] It is made from the following raw materials:

[0094] Donkey-hide gelatin 3.5g, astragalus 140g, angelica 105g, jujube 70g, antler gum 10.5g.

[0095] 1) Take the above five flavors, extract the volatile oil from Angelica sinensis by distillation, put 8 times the amount of β-cyclodextrin in the obtained volatile oil into a suitable glass container, add water 6 times the amount of β-cyclodextrin, and put it on a magnetic heating stirrer. Stir at constant temperature to 30°C, take the above-mentioned volatile oil, dilute it with absolute ethanol at a ratio of 1:1, drop it into the β-cyclodextrin solution, stir at constant temperature for 3 hours, put it in a refrigerator at 4°C for 24 hours, and filter it with suction for 40 ℃ dry for 4 hours, set aside;

[0096]2) Take the three herbs of angelica dregs, astragalus, and jujube, add water and decoct twice for 3 and 2 hours respectively,...

Embodiment 3

[0100] Embodiment 3 Preparation of pharmaceutical granules of the present invention

[0101] It is made from the following raw materials:

[0102] Donkey-hide gelatin 6.5g, astragalus 260g, angelica 195g, jujube 130g, antler gum 19.5g.

[0103] 1) the step of preparing active substance is the same as 1)~4) of embodiment 2,

[0104] 2) The active component obtained in 1) is pulverized, granulated, and dried to obtain granules.

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PUM

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Abstract

The present invention is medicine for treating thrombocytopenia and anemia and its preparation process and quality control method, and belongs to the field of Chinese medicine technology. The medicine is prepared with donkey-hide gelatin 3.5-6.5 weight portions, astragalus root 140-260 weight portions, angelica 105-195 weight portions, date 70-130 weight portions and antler gelatin 10.5-19.5 weight portions. It has the functions of invigorating qi, nourishing blood, and benefiting kidney and spleen, and is used in treating thrombocytopenia and anemia. It has also certain curative effect on leucopenia caused by radiotherapy and chemotherapy.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine and its preparation method and quality control method. Background technique [0002] Thrombocytopenia, anemia, and leukopenia caused by radiotherapy and chemotherapy are common clinical diseases. Therefore, it is very important to study a highly efficient and non-toxic therapeutic drug. It can improve people's quality of life, improve work efficiency, and benefit mankind. very important meaning. [0003] This requires us to produce high-quality products, but the original quality control method is to use dual-wavelength thin-layer chromatography to determine the content of astragaloside IV in this product Astragalus membranaceus, and the determination results are not particularly accurate. We have improved the quality control method of this preparation, carry out effective quality control to the product. Contents of the invention [0004] The invention provides a medicine for treating thrombocy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61P7/00A61P7/06A61K35/36A61K35/32
Inventor 解均秀于江波陈志国仲崇林暴庆发刘乃发孟繁林
Owner JILIN AODONG GRP LIYUAN PHARM CO LTD
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