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A Chinese traditional medicinal composition for treatment of endometriosis and its preparation method

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formulation, drug delivery, etc., can solve difficult problems such as treatment

Active Publication Date: 2007-04-11
CHENGDU HUASUN GRP INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the above reasons, it is more difficult to treat

Method used

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  • A Chinese traditional medicinal composition for treatment of endometriosis and its preparation method

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Experimental program
Comparison scheme
Effect test

experiment example 1

[0046] Experimental example 1 Determination of grinding degree and extraction time

[0047] According to the proportioning dose of the pharmaceutical composition, three portions of cassia twig 60 g, asarum 30 g, and myrrha 60 g were weighed, and the specifications of the three portions were decoction pieces, 10 mesh, and 20 mesh respectively. Add 6 times the amount of water respectively, and carry out steam distillation. The results are shown in Table 1:

[0048] Extraction time (hours)

[0049] From the above results, it can be seen that 10 mesh has the least amount of oil extraction, and 20 mesh medicinal powder is likely to cause paste pot during production. Compared with 20 mesh, the oil extraction rate of decoction pieces has reached 85.7%, and there is one less process, which saves energy. Therefore, it is chosen to directly extract the oil with decoction pieces. After 8 hours of extraction, the essential oil has been basically extracted. After 1 hour of heat...

experiment example 2

[0050] Experimental example 2 Optimization experiment of inclusion process of Asarum volatile oil

[0051] Taking the ratio of volatile oil and β-cyclodextrin (A), the amount of water added (B), the inclusion temperature (C), and the stirring time (D) as the investigation factors, select different levels, according to L9 (3 4 ) orthogonal table for inclusion, and then extract with trace volatile oil extractor respectively, calculate the utilization rate of volatile oil, and carry out analysis of variance, which adopts orthogonal polynomial regression method.

[0052] factor

Level

A

Volatile oil: β-CD(ml / g)

B

Add water

(ml)

C

inclusion temperature

(°C)

D.

Stiring time

(h)

1

1∶4

60

40

0.5

2

1∶6

80

60

1.0

3

1∶8

100

80

1.5

[0053] A

Volatile oil: β-CD

B

Add water

C

inclus...

experiment example 3

[0058] Experimental Example 3 Identification Test of Pharmaceutical Composition Preparations

[0059] TLC characterization of Radix Paeoniae Rubra, Paeoniflorin was purchased from China Institute for the Control of Pharmaceutical and Biological Products, No. 0736-9811. The upper layer solution of chloroform-ethyl acetate-methanol-formic acid (40:5:10:0.2) and ethyl acetate-methanol-water (8:3:2.5) of the TLC development system of Radix Paeoniae Rubra was used for development. The effect of the former is not satisfactory, but the paeoniflorin spots obtained by the former are clear and concentrated, and the negative control substance prepared by the same method has no interference. The color developer originally used 5% vanillin sulfuric acid solution, but when the color developer was heated for a long time, the spots would turn black, and the color development time was not easy to grasp, so it was changed to 50% phosphoethanol solution of 5% vanillin. Sensitive and specific, t...

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Abstract

This invention provides a medicinal composition for treatment of endometriosis and its preparation method and its controlling method. This medicinal composition is prepared by using the medical ingredients of common peony root, Chinese angelica root, cattail pollen, chuanxiong ligusticum rhizome, cassiabarktree twig, yanhusuo rhizome, Chinese thorowax root, membranous milkvetch root, malaytea scurfpea fruit and myrrh. Curative effectiveness of this medical composition in treating endometriosism is definitude with fast action but without toxin and side effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, a preparation method and a quality control method of the composition, in particular to a traditional Chinese medicine composition for treating endometriosis, and to a preparation method and a quality control method of the composition. Background technique [0002] Endometriosis is one of the common and frequently-occurring diseases in gynecology. In recent years, the incidence rate has increased significantly. The incidence rate among women of childbearing age is 10-20%, and about 40% of endometriosis is associated with infertility. Endometriosis seriously affects women's physical and mental health. Although endometriosis has been discovered for more than 100 years, its etiology and pathogenesis are still unclear, and there is no ideal method for treatment. In recent decades, Western medicine has been exploring the application of sex hormone drugs to treat endometriosis. Currently t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K9/00A61K9/02A61K9/10A61K9/16A61K9/20A61K9/48A61P15/00
Inventor 任明非杨世林万方王卫华
Owner CHENGDU HUASUN GRP INC LTD
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