Check patentability & draft patents in minutes with Patsnap Eureka AI!

Nano-safflower flavone injection prepn. and its prepn. method

A technology of safflower flavonoids and injection preparations, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., and can solve the problems of unretrieved nano safflower flavone injection preparations

Inactive Publication Date: 2007-04-18
张晴龙
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After reviewing the literature and patents, no information on nano-safflower flavone injection preparations was found

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] (1) Extraction of effective parts of safflower flavonoids:

[0115]Get 226.4 grams of safflower, pulverize it, put it into an ultrasonic extraction tank, add 50% ethanol of 4 times the volume of the safflower mass, and ultrasonically extract it for 25 minutes. The concentration temperature is 40°C, the vacuum degree is 0.1 atmosphere, and the concentrated solution is obtained, which is left to stand for 12 hours, centrifuged, and the supernatant is placed on a D101 macroporous adsorption resin column. Elute with 4 times the column volume of 60% ethanol, collect the eluent, concentrate the ethanol in the eluent rotary wiper to the end, control the concentration temperature at 40°C, and vacuum at 0.1 atmosphere to obtain the concentrated solution, dry at low temperature, and obtain 12 grams of safflower flavonoids extract; 【50% safflower flavonoids content】

[0116] (2) Preparation of nano safflower flavonoids:

[0117] The prescription is: 12 grams of safflower flavono...

Embodiment 2

[0125] (1) Extraction of effective parts of safflower flavonoids:

[0126] Get 135.6 grams of safflower, crush it, put it into an ultrasonic extraction tank, add 70% ethanol with 8 times the volume of the safflower mass, and extract ultrasonically for 40 minutes, control the extraction temperature to 40°C and concentrate the ethanol in the extracting liquid rotary scraping device until it is exhausted. The concentration temperature is 45°C, the vacuum degree is 0.2 atmospheres, and the concentrated solution is obtained, which is left to stand for 24 hours, centrifuged, and the supernatant is placed on a D101 macroporous adsorption resin column, washed with 6 times the column volume of distilled water, and the washing solution is discarded, and then Elute with 8 times the column volume of 80% ethanol, collect the eluent, concentrate the ethanol in the eluent rotary wiper to the end, control the concentration temperature at 45 ° C, and vacuum at 0.2 atmospheres to obtain a concen...

Embodiment 3

[0136] (1) Extraction of effective parts of safflower flavonoids:

[0137] Get 181.8 grams of safflower, pulverize it, put it into an ultrasonic extraction tank, add 60% ethanol of 6 times the volume of the safflower mass for ultrasonic extraction for 35 minutes, control the extraction temperature to 35°C and concentrate the ethanol in the extracting liquid rotary scraping device until it is completely controlled. The concentration temperature is 42°C, the vacuum degree is 0.15 atmospheres, and the concentrated solution is obtained, which is left to stand for 16 hours, centrifuged, and the supernatant is placed on a D101 macroporous adsorption resin column, washed with 4 times the column volume of distilled water, and the washing solution is discarded, and then Elute with 6 times column volume of 70% ethanol, collect the eluate, concentrate the ethanol in the eluent rotary wiper to the end, control the concentration temperature at 42°C, and vacuum at 0.15 atmospheres to obtain ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A nano-carthamiflavone medicine in the form of liquid injection, powder injection, or perfusion is prepared from carthamiflavone (50-85%) extracted from safflower, medical carrier and medical auxiliary. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a nano safflower flavonoid injection preparation and a preparation method thereof. Background technique [0002] Safflower is the dried flower of Carthamustinctorius L., an annual herb of Compositae. It is one of the commonly used traditional Chinese medicines for promoting blood circulation and removing blood stasis. Active ingredients, the main active ingredient in safflower injection currently on the market is total flavonoids, flavonoids can significantly inhibit platelet aggregation induced by ADP, thrombin, arachidonic acid, and also inhibit platelet activating factor-mediated However, in clinical application, the stability of safflower injection is poor ["Shizhen Guoyi Guoyao" 2001, Vol. Reactions: 1. Anaphylactic shock; 2. Drug eruption; 3. Fever [Safflower Injection Causes Anaphylaxis, "Pharmaceutical Herald", 2000, 19(6): 609] ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/286A61K9/10A61K9/14A61P7/02A61P9/10
Inventor 张晴龙
Owner 张晴龙
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com