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Antineoplastic medical composite compatibility with oldenlandia, ginseng and astragalus root

A technology of Hedyotis diffusa and composition, applied in the field of medicine

Inactive Publication Date: 2007-05-02
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, at present, there is no report on the use of Hedyotis diffusa, Ginseng and Radix Astragali to combine prescriptions for anti-tumor drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] Example 1 Preparation of Hedyotis diffusa Extract

[0147] The preparation process of Hedyotis diffusa extract:

[0148] Get Hedyotis diffusa, pulverize into coarse powder, according to the percolation method (Appendix IO of Chinese Pharmacopoeia 2000 edition one) under the liquid extract and extract item, use 80% ethanol as solvent, soak for 24 hours, slowly percolate , the filtrate is concentrated under reduced pressure until there is no alcohol smell, diluted with water to an amount equivalent to 1g of the original medicinal material per 1ml, refrigerated, left to stand for 12 hours, filtered, and the filtrate is added with ethanol for three gradient alcohol precipitations, the first time the alcohol content 60%, the second time the alcohol content is 70%, the third time the alcohol content is 80%, each time it is refrigerated for 24 hours, filtered, the filtrate is concentrated under reduced pressure to a relative density of 1.10-1.15, and spray-dried to obtain fina...

Embodiment 2

[0157] Example 2 Preparation of ginseng extract with polysaccharide as the main active ingredient, namely ginseng polysaccharide

[0158] Ginseng polysaccharide preparation process:

[0159] Take raw sun-dried ginseng, chop it up, use 75% ethanol, reflux extract for 4 hours, filter, dry the dregs, add water to decoct five times, combine the decoction liquid, add 0.3% activated carbon, stir for 30 minutes, let stand overnight, Filtrate, pass the filtrate through a resin column, collect the effluent, concentrate under reduced pressure, add ethanol to make the alcohol content reach 95%, refrigerate, filter, take the precipitate and wash it with acetone, drain the acetone, take out the precipitate and dry it at 60-80°C. Smash and serve.

[0160] Ginseng Polysaccharide Identification Experiment

[0161] (1) Take about 0.2g of this product, add 5ml of water to dissolve, add 5 drops of alkaline copper tartrate test solution, heat to produce a red precipitate, cool, filter, take the...

Embodiment 3

[0169] Example 3 Preparation of ginseng extract with total saponins as the main active ingredient, i.e. total ginsenosides

[0170] Preparation process of total ginseng saponins:

[0171] Take the ginseng medicinal material, crush it into fine particles, and extract twice with ethanol under reflux, each time for 3 hours, add 10 times the amount of alcohol each time, combine the extracts, refrigerate, filter, recover the ethanol from the filtrate and concentrate it to a thick paste, add water to an appropriate amount ( Make each 1ml equivalent to 1g of the original medicinal material), stir well, refrigerate, filter, add the filtrate to the processed macroporous resin column, first elute with 2V ~ 3V column volume of water, discard the washing solution, and then Elute with 3 times column volume of 80% ethanol, collect the eluate, recover the ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.30-1.35, and dry it in vacuum to obtain the prod...

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PUM

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Abstract

A composite medicine for preventing and treating tumor is proportionally prepared from oldenlandia or its extract, ginseng or its extract, and astragalus root or its extract. Its preparing process is also disclosed.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition for anti-tumor diseases prepared from Hedyotis diffusa, ginseng and astragalus or extracts thereof, and a preparation method and application thereof, belonging to the technical field of medicine. 2. Background technology [0002] At present, cancer has become the number one killer of human beings, and the incidence and mortality of cancer have increased significantly in recent decades. A tumor is a developing or mature normal cell in the human body. Under the long-term action of certain adverse factors, a certain cell group, a new organism formed by excessive proliferation or abnormal differentiation, forms a local tumor. However, it is different from normal tissue cells. It does not grow according to the metabolism of normal cells, and becomes unconstrained and controlled, and will not die normally, resulting in abnormal cell morphology, function and metabolism, which can destroy normal cells. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/76A61K36/481A61K36/258A61P35/00
Inventor 黄振华
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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