Chinese medicinal extract having blood sugar-lowering activity, its preparation process, composition and use

A drug and applied technology, which is applied in the field of traditional Chinese medicine extracts, preparation methods, compositions and uses with hypoglycemic activity, and can solve problems such as application restrictions, irritation, and lactic acid poisoning

Inactive Publication Date: 2011-04-20
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of drug has been used to treat diabetes in the late 1950s, the incidence of adverse reactions is very high, mainly including obvious digestive side effects such as gastrointestinal irritation and lactic acid poisoning, which limit its application

Method used

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  • Chinese medicinal extract having blood sugar-lowering activity, its preparation process, composition and use
  • Chinese medicinal extract having blood sugar-lowering activity, its preparation process, composition and use
  • Chinese medicinal extract having blood sugar-lowering activity, its preparation process, composition and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1. water extraction extract

[0049] Pueraria japonica (Snake mushroom, Balanophora japonica Mak.) whole herb 100g, heat reflux with 500g distilled water, extract three times (500ml water / time), extract 1 hour each time, extract 26.0g water extract after concentrating under reduced pressure, dissolve In 50 ml of water, add ethanol until the alcohol content reaches 70% (volume ratio), precipitate, filter, and concentrate the filtrate to dryness to obtain 14.0 g of a yellow powdery solid.

[0050] The filtrate part is separated by macroporous resin column:

[0051] 14.0 g of the filtrate was dissolved in 50 ml of water, added to a 100 g macroporous resin column (S-8), washed with distilled water until the effluent was colorless, then eluted with ethanol until the effluent was colorless, and the ethanol eluted part was concentrated to obtain 7.5g. The macroporous resin is washed with water until the effluent is alcohol-free (macroporous resin regeneration).

Embodiment 2

[0052] Embodiment 2. alcohol extraction extract

[0053] Take 2500g of the whole herb of Balanophora inovolucrata Hook f., heat reflux with 95% EtOH, extract three times (10L 95% EtOH / time), slowly heat to boiling, extract for 1 hour each time, and concentrate the extract under reduced pressure 532.0 g of 95% EtOH extract was obtained, suspended in 1500 ml of water, filtered, and the filtrate was extracted three times with ethyl acetate (1500 ml / time), the extracts were combined, and the solvent was recovered under reduced pressure to obtain 210.0 g of a yellow powdery solid.

Embodiment 3

[0054] Embodiment 3. ethyl acetate extraction extract

[0055] Multi-core snake mushroom (Balanophora polyandra Griff.) whole herb 1000g, heated to reflux with 5000ml of petroleum ether, extracted three times, 1 hour each time, the extract was concentrated under reduced pressure to obtain 56.0g of petroleum ether extract; 5000ml of the ester was heated to reflux, extracted three times, each time for one hour, the extracts were combined, and the solvent was recovered under reduced pressure to obtain 173.0g of ethyl acetate extraction fraction.

[0056] Ethyl acetate extraction part is separated by macroporous resin:

[0057] 173.0 g of the filtrate was dissolved in 1000 ml of water, filtered, and the filtrate was added to a 1000 g macroporous resin column (S-8), washed with distilled water until the effluent was colorless, then eluted with ethanol until the effluent was colorless, and ethanol was eluted Partial concentration gave 113.0 g. The macroporous resin is washed with ...

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Abstract

The invention discloses a hypoglycemic extract from a Balanophora L, a preparation method thereof, a drug combination containing the Balanophora L or the extract thereof, as well as use as drugs and health products of the Balanophora L or the extract thereof and the drug combination, especially the use for preparing drugs and health products which treat and prevent metabolic diseases relevant to the diabetes and complication thereof or the like.

Description

technical field [0001] The present invention relates to extracting an extract capable of lowering blood sugar from a plant of the genus Balanophora (Balanophora L), a preparation method of the extract, a pharmaceutical composition containing a plant of the genus Balanophora (Balanophora L) or an extract of the genus, and snake The use of Balanophora L or its extract and its pharmaceutical composition as medicine, especially for the preparation of medicines and health care products for treating and preventing diabetes and its complications and other related metabolic diseases. Background technique [0002] According to the relevant data of WHO, the prevalence rate, disability rate, mortality rate and overall health hazard of diabetes have been ranked third among non-communicable diseases. It has become a serious threat to human health after cardiovascular and cerebrovascular diseases and tumors. the third leading disease. There are 130 million people with diabetes in the wor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/10
Inventor 吉腾飞叶菲苏亚伦田金英叶峰辛冰牧丛维娜冯孝章
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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