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Application of beta-protein inhibitor in preparation of medicament for treating genetic correlated disease

A technology for inhibiting proteins and diseases, applied in genetic material components, drug combinations, gene therapy, etc., can solve problems such as the impact of acetylation levels

Inactive Publication Date: 2007-05-30
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is worth noting that the agents affecting histone acetylation currently used in clinical trials are all histone deacetylase inhibitors. Although these agents have clear anticancer effects, they almost inhibit all histone deacetylation in the body. acetylase activity
Undoubtedly, such preparations have a great impact on the acetylation level of histones in normal cells, and will produce great side effects after being made into medicine
In fact, the non-specificity of the action of these preparations is the key to limit their druggability

Method used

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  • Application of beta-protein inhibitor in preparation of medicament for treating genetic correlated disease
  • Application of beta-protein inhibitor in preparation of medicament for treating genetic correlated disease
  • Application of beta-protein inhibitor in preparation of medicament for treating genetic correlated disease

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Embodiment

[0035] 1 Materials and methods

[0036] 1.1 Antibodies and Reagents

[0037]Beta-arrestin 1 mouse anti, p27 and c-Jun antibodies were purchased from BD Biosciences (San Jose, CA). Beta-arrestin polyclonal rabbit antibody was a gift from Robert J. Lefkowitz (Duke University Medical Center, Durham). p300 CT, CBP, histone H4, acetylated histone H4 and H3 antibodies were purchased from Upstate Biotechnology (Lake Placid, NY). Mouse anti-12CA5 against HA-tag was purchased from Roche Molecular Biochemicals (Indianapolis, IN). Tip60 antibody was purchased from Santa Cruz Biotechnology (Santa Cruz, CA). CREB antibody was purchased from Cell Signaling Technology (Beverly, MA). Texas Red-conjugated goat anti-mouse IgG and FITC-conjugated goat anti-rabbit IgG were purchased from Jackson Immunoresearch (West Grove, PA). IRDye TM 800CW-conjugated affinity purified anti-mouse IgG and anti-rabbit IgG were purchased from Rockland Inc. (Gilbertsville, PA). The following antibodies were ...

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Abstract

The invention discloses a beta-inhibiting protein, nucleonic sequence and application of composition with nucleonic sequence to treat relative disease with histone acetylated reduction level, which also relates to the application of delta opitum receptor stimulating agent or k opitum receptor exciting agent to treat relative disease with histone acetylated reduction level. The invention provides a drug sieving method from candidate material to treat relative disease with histone acetylated reduction level.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of human β-arrestin in the preparation of medicines for diseases associated with reduced histone acetylation levels. Background technique [0002] Recent studies have found that many human diseases are related to disorders of epigenetic regulation, and epigenetic therapy will become an effective means to address these diseases. Moreover, many such formulations are currently undergoing preclinical studies (Egger et al. Nature 2004;429:457-463). Histone acetylation plays an important role in epigenetic regulation and is known as an early switch in eukaryotic gene transcription (Grewal et al. Science 2003; 301: 798-802; Fry et al. Science 2002; 295: 1847-1848) . [0003] Recent studies have found that the reduced level of histone acetylation is an important cause of cell carcinogenesis and many neurological diseases, and preparations that can promote the increased level ...

Claims

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Application Information

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IPC IPC(8): A61K38/04A61K38/33A61K39/395A61K48/00A61P35/00A61P25/00
Inventor 马兰裴钢康九红施裕丰向斌鲍国斌苏文娟
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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