Hydrogel interferon formulations

A technology of interferon and hydrogel, applied in the direction of non-active ingredient medical preparations, active ingredient-containing medical preparations, cyclic peptide ingredients, etc., to achieve the effect of easy operation and high bioavailability

Inactive Publication Date: 2007-06-20
ARES TRADING SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0027] As with all protein-based drugs, the main challenge with interferon as a therapeutic agent is to maintain blood levels in therapeutically effective amounts for a certain period of time without increasing the injected dose and without potentially associated side effects

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Embodiment Construction

[0036] Unless the broader meaning of this definition is specifically stated otherwise, the following paragraphs will define the different chemical components that constitute the compound of the present invention and apply to the entire specification and claims.

[0037] "Interferon" or "IFN" as used herein means any molecule as defined in the literature, including, for example, any type of interferon mentioned in the background of the invention. Specifically, IFN-α, IFN-β, and IFN-γ are included in the above definition. The interferon of the present invention is preferably IFN-β. IFN-β suitable for the present invention can be obtained through commercial products, such as Rebif  (Serono), Avonex  (Biogen) or Betaferon  (Schering).

[0038] As used herein, the term "interferon-β (IFN-β)" refers to include: fibroblast interferon, especially human fibroblast interferon, refers to isolated and obtained from biological fluids or obtained from eukaryotic or prokaryotic cells by recom...

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Abstract

The present invention is related to pharmaceutical Poloxamer hydrogel formulations containing an interferon. In particular, the invention relates to sustained release hydrogel formulations of interferon-beta, method of preparation and use thereof.

Description

Invention field [0001] The present invention relates to a hydrogel pharmaceutical preparation containing interferon. Specifically, the present invention relates to an interferon-beta hydrogel sustained-release preparation, a preparation method thereof, and application of the preparation. Background of the invention [0002] It has been proven that recombinant protein drugs can provide unique therapeutic effects on several diseases that could not be treated before, and many new protein drugs are under development. [0003] Protein is usually administered parenterally, which will result in rapid elimination of protein from the circulatory system. In order to maintain a therapeutically effective blood drug level, large doses or frequent administration are often required. This method is inconvenient and has potential undesirable side effects. It is possible to avoid the above problems by using a system capable of sustained or controlled release of protein. [0004] Compared with the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61K9/00A61K38/13A61K38/21A61K47/34
CPCA61K38/215A61K38/13A61K38/21A61K47/10A61K9/0014A61K47/34A61P21/00A61P25/00A61P25/28A61P37/00A61P43/00A61K2300/00
Inventor M·D·德尔克托I·赞巴蒂S·波姆比利P·艾斯波斯托
Owner ARES TRADING SA
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