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Medicine composition prepared mainly from glycyrrhizic acid or its salt, ginseng and glossy ganoderma

A composition, technology of glycyrrhizic acid, applied in the field of medicine

Inactive Publication Date: 2010-05-12
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the use of glycyrrhizic acid or its pharmaceutically acceptable salts, ginseng or its extracts, and ganoderma lucidum or its extracts to make compatible prescriptions for the treatment of hepatitis.

Method used

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  • Medicine composition prepared mainly from glycyrrhizic acid or its salt, ginseng and glossy ganoderma
  • Medicine composition prepared mainly from glycyrrhizic acid or its salt, ginseng and glossy ganoderma
  • Medicine composition prepared mainly from glycyrrhizic acid or its salt, ginseng and glossy ganoderma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] Example 1 Preparation of ginseng extract, namely ginseng polysaccharide with polysaccharide as the main active ingredient

[0145] Ginseng polysaccharide preparation process:

[0146] Take ginseng, chop it, extract with 75% ethanol, reflux for 4 hours, filter, dry the medicine residue, add water and cook five times, combine the decoction, add 0.3% activated carbon, stir for 30 minutes, let stand overnight, filter Pass the filtrate through the resin column, collect the effluent, concentrate under reduced pressure, add ethanol to make the alcohol content reach 95%, refrigerate, filter, take the precipitate and wash with acetone, drain the acetone, take out the precipitate and dry it at 60~80℃, and crush it. Got.

[0147] Ginseng polysaccharide identification test

[0148] (1) Take about 0.2g of this product, add 5ml of water to dissolve it, add 5 drops of alkaline copper tartrate test solution, heat it to produce a red precipitate, cool, filter, take the filtrate and add 1 drop...

Embodiment 2

[0157] Example 2 Preparation of ginseng extract with total saponins as main active ingredients, namely total ginsenosides

[0158] Preparation process of total ginsenosides:

[0159] Take the ginseng medicinal material, crush it into fine particles, extract twice with ethanol reflux, 3 hours each time, add 10 times the amount of alcohol each time, combine the extracts, refrigerate, filter, recover the ethanol and concentrate the filtrate to a thick paste, add water to an appropriate amount ( Make each 1ml equivalent to 1g of original medicinal materials), stir well, refrigerate, and filter. The filtrate is added to the processed macroporous resin column, first eluted with 2V~3V column volume of water, discarded the washing liquid, and then Elute with 3 times the column volume of 80% ethanol, collect the eluate, recover the ethanol and concentrate it under reduced pressure to a thick paste with a relative density of 1.30 to 1.35, and vacuum dry to obtain.

[0160] Identification of ...

Embodiment 3

[0175] Example 3 Preparation of Ganoderma lucidum extract, namely Ganoderma lucidum polysaccharide, with polysaccharide as the main active ingredient

[0176] Ganoderma lucidum polysaccharide preparation process

[0177] Take Ganoderma lucidum medicinal materials, crush them into coarse particles, add 3 times the amount of water to moisten overnight, decoct three times the next day, add 12 times the amount of water for 3 hours for the first time, add 10 times the amount of water for 2 hours for the second time, and add water 10 times for the third time for 1 hour. Double the amount, combine the decoction, filter, concentrate the filtrate to a relative density of 1.02~1.06, let it cool, add ethanol to make the alcohol content 65%, stir well, place at 4°C for 24 hours, filter, and recover the ethanol from the filtrate to No alcohol smell, filter, add ethanol to make the alcohol content 80%, stir well, place at 4℃ for 24 hours, filter, the filtrate recovers ethanol to no alcohol smel...

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Abstract

The present invention belongs to the field of medicine technology, and is especially one medicine composition for treating hepatitis and its preparation process and use. The medicine composition consists of glycyrrhizic acid or its pharmaceutically acceptable salt 4-800 weight portions, ginseng 250-16000 weight portions, and glossy ganoderma 500- 20000 weight portions. It may consist of glycyrrhizic acid or its pharmaceutically acceptable salt, the extract of ginseng and the extract of glossy ganoderma. It may be prepared into different forms. The medicine composition has the synergistic effect of the components, high stability, high effect and wide application.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of glycyrrhizic acid or its pharmaceutically acceptable salt, ginseng or its extract, and ganoderma or its extract, and a preparation method thereof, belonging to the technical field of medicine. 2. Background technology [0002] Hepatitis is one of the common serious infectious diseases, among which viral hepatitis is the main one. According to incomplete statistics, 8-10% of the population in my country are currently carriers of hepatitis B virus, and a considerable number of new patients are still increasing every year. Viral hepatitis can be divided into types: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Liver fibrosis refers to the pathological process of abnormal proliferation of connective tissue in the fibrous structure of the liver when hepatocytes undergo necrosis and inflammatory stimulation. The milder is called liver fibrosis, and the severer c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/484A61K36/258A61K36/074A61P1/16A61P31/14A61P31/20
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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