Medicine composition for treating tumor

A composition and drug technology, which is applied in the field of pharmaceutical compositions for the treatment of tumors, can solve problems such as unclear effective substances and curative effects, restrictions on the use of traditional Chinese medicine, and incompatibility with the modernization and internationalization of traditional Chinese medicine.

Inactive Publication Date: 2007-06-27
GREEN VALLEY GROUP CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the active substances and curative effects of the current anti-tumor traditional Chinese medicine are not yet clear, and the quality control indicators are not strict, so that the use of traditional Chinese medicine in treatment is greatly restricted, and it does not meet the requirements of modernization and internationalization of traditional Chinese medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Effects of Sophora flavescens alkaloids and triterpene acid composition in Ligustrum lucidum on S180 sarcoma

[0019] Seventy Kunming mice were taken, half male and half male, and they were given normal water and diet for 7 days before the experiment. Aseptically take the tumor source of S180 sarcoma, S180 sarcoma 1×10 7 / ml cell suspension, inoculate 0.2ml in the armpit of each mouse. Dosing began 24 hours after inoculation, once a day, for 10 consecutive days; at the end of the administration, the mice were sacrificed, the solid tumors were weighed, and the tumor weight difference between the administration group and the model group was compared, and the tumor inhibition rate was calculated.

[0020] The formula for calculating tumor inhibition rate:

[0021] Tumor inhibition rate (%)=[(average tumor weight of blank group-average tumor weight of treatment group)] / average tumor weight of blank group×100%.

[0022] Table 1 is the effect of the pharmaceutica...

Embodiment 2

[0027] Example 2, the influence of Sophora flavescens alkaloids and triterpene acid composition in Ligustrum lucidum on Lewis lung cancer

[0028] Seventy C57BL / 6 mice were taken, half male and half male, and they were given normal water and diet for 7 days before the experiment. The tumor source of Lewis lung cancer was collected aseptically, and 1mm3 was inoculated into the underarm of each mouse in C57BL / 6 mice; 24 hours after the inoculation, the drug was administered once a day for 12 consecutive days. At the end of the administration, the mice were killed, and the solid tumors were weighed to compare the difference in tumor weight between the administration group and the model group, and the tumor inhibition rate was calculated.

[0029] The formula for calculating tumor inhibition rate:

[0030] Tumor inhibition rate (%)=[(average tumor weight of blank group-average tumor weight of treatment group)] / average tumor weight of blank group×100%.

[0031] Table 2 is the eff...

Embodiment 3

[0034] Example 3, Effects of Sophora flavescens alkaloids and triterpene acid composition in Ligustrum lucidum on leukocytes of chemotherapy-bearing tumor-bearing mice

[0035] Liver cancer that had grown well 8-10 days after transplantation was selected, and the cancer cell suspension was prepared with normal saline at a ratio of 1:3, and inoculated in the armpit of mice after routine disinfection, 0.2 ml each. Each mouse was injected with cyclophosphamide 20mg / kg every day, and at the same time, each treatment drug was administered orally for 10 consecutive days, and then fed for 10 days after drug withdrawal.

[0036] After 5 days of medication, 10 days of medication, 5 days of drug withdrawal, and 10 days of drug withdrawal, 10 tumor-bearing mice in each group were taken from the tail vein to collect blood, measure the total number of peripheral white blood cells, and weigh their body weight.

[0037] Table 3 shows the effect of the pharmaceutical composition on leukocytes...

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PUM

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Abstract

The present invention discloses a kind of Chinese medicine composition for treating tumor. The Chinese medicine composition consists of alkaloid extracted from flavescent sophora root and oleanolic acid and other triterperic acid compound extracted from privet fruit in certain ratio. Of the Chinese medicine composition, the flavescent sophora root extract contains flavescent sophora alkaloid in 50-100 %, and the privet fruit extract has oleanolic acid content in triterperic acid compounds in 50-99.5 %. The components in the Chinese medicine composition can generate synergistic effect. The experiment on S180 sarcoma and Lewis lung cancer in animal's body and other pharacodynamic experiment show that the Chinese medicine composition has effect of reducing leucopenia and other tumor radiotherapy and chemotherapy toxic side effects. The Chinese medicine composition may be used by patient regularly.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating tumors, in particular to a pharmaceutical composition composed of Sophora flavescens alkaloid extracted from Sophora flavescens and triterpene acid extracted from Ligustrum lucidum. Background technique [0002] Malignant tumors—cancer has become one of the major diseases that are common and seriously threaten human life and quality of life. According to the report of the World Health Organization in 1997, in 1996, among the 5.8 billion people in the world, about 6.3 million people died of cancer, accounting for about 12% of the total number of deaths, of which nearly 60% died of lung cancer, gastric cancer, breast cancer, colorectal cancer, Oral cancer, liver cancer, cervical cancer and esophageal cancer, malignant tumors are the second leading cause of death after cardiovascular diseases. Since 1996, more than 10.3 m...

Claims

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Application Information

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IPC IPC(8): A61K36/638A61K9/00A61P35/00
Inventor 刘梅英李廷钊毛士龙孟庆国王茵吴云鸣法杨胡洪涛陈兆伟
Owner GREEN VALLEY GROUP CO LTD
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