Even fluid front for liquid sample on test strip device

Inactive Publication Date: 2001-09-13
SYNTRON BIORES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A major problem with this type of device is that as the fluid progresses through the membrane, the front edge of the fluid is uneven.
The uneven fluid front will cause the results to be smeared, produce false negatives and make the results difficult to detect.
An uneven fluid front can arise for a variety of reasons, for example, because the sample is not uniformly applied to the absorbent membrane.
Thus, the user of those devices is not given the time to test additional samples.
Thus, the diffusively bound labeled reagent stays within the absorbent membrane and does not migrate into the fluid sample, which would otherwise destroy performan

Method used

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  • Even fluid front for liquid sample on test strip device
  • Even fluid front for liquid sample on test strip device
  • Even fluid front for liquid sample on test strip device

Examples

Experimental program
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Example

EXAMPLE II

Analytical Test Device with Sample Aperture on the Top

[0102] This example describes the method and analytical test device depicted in FIG. 13 containing a sample aperture on the top.

[0103] The assay procedure is performed using anti-hCG antibody to form the second complex and an anti-hCG-colloidal gold compound to form the first complex. A fluid sample can be collected at any time of day, but for best results, it is best to test the first urine of the morning because it contains the highest concentration of hCG. The fluid sample is at least 1 cubic centimeter (hereinafter "cc") of urine suspected of containing hCG; the assay is performed at ambient temperatures not below 15.degree. C. or exceeding 30.degree. C. The 1 cc of urine is added to the sample aperture 510 on the top by pipette. The fluid sample contacts contacting surface 534. The analytical test device is then tilted so that fluid sample contacts absorbent membrane 544 located at slope 532. Within 3 minutes visib...

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Abstract

The present invention provides an analytical test device for conducting assays of biological fluids. Methods for carrying out the assays with the disclosed analytical test devices are also provided.

Description

[0001] This invention relates to a novel analytical test device for analysis of biological fluids such as urine. The invention further relates to methods for detecting analytes in fluids using the test device.BACKGROUND INFORMATION[0002] The sampling and testing of biological fluids such as urine for the presence of analytes provide important information regarding various health-related matters, including pregnancy and conception.[0003] In recent years, test devices have undergone nearly continuous refinement in an effort to simplify and speed the process of detecting selected ligand in fluids. As a result of this work, current test devices use an immunoassay for determining pregnancy or conception. In these devices a reagent, such as an antibody, specifically reacts with an analyte to form a complex, which can usually be detected by the unaided eye.[0004] Current pregnancy test devices assay for hormones associated with pregnancy, such as, for example, chorionic gonadotrophin (here...

Claims

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Application Information

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IPC IPC(8): G01N33/543G01N33/558
CPCG01N33/54366G01N33/558Y10S436/808Y10S435/97Y10S435/805Y10S436/81Y10T436/112499
Inventor LEE, JIN PO
Owner SYNTRON BIORES
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