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Process for optimizing milk production

a technology optimizing milk production, which is applied in the field of optimizing milk production, can solve the problems of not providing the necessary levels of methionine and other essential amino acids, reducing the effect of rumen bacteria on free amino acids, and reducing the effect of rumen bacteria on the production of milk,

Inactive Publication Date: 2005-03-17
NOVUS INTERNATIONAL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a process for formulating a ruminant food ration that meets the nutritional requirements of ruminants for methionine. This process involves identifying the methionine needs of the ruminant and formulating a ration that includes one or more grains, a hydroxy analog of methionine, and optionally a bypass fat. The hydroxy analog of methionine is added separately from any bypass fat and is assumed to be at least partially absorbed by the ruminant. The process avoids the need to coat or protect the methionine source from rumen microflora and ensures a predictable milk response while also avoiding excess levels of fats or non-essential amino acids. The invention also allows for the replacement of some of the UIP in a balanced ration with a lower cost source of methionine, resulting in cost savings.

Problems solved by technology

While amino acids can be added directly to the diets of monogastric animals to overcome nutritional deficiencies, free amino acids are rapidly degraded by rumen bacteria and are of little or no practical benefit in alleviating amino acid deficiencies in ruminants.
It is difficult, however, to accurately deliver needed levels of methionine and other essential amino acids without providing excess levels of other non-essential amino acids and, any excess nitrogen which UIP delivers to the rumen must be degraded and eliminated by the animal.
Consequently, formulating feeds which satisfy the methionine requirements using UIP sources is not only expensive, it can also affect cow health and productive status.
The practical application of rumen protected methionine, however, has presented some challenges.
For others, pelleting, expander conditioning, mixing, and other normal milling practices fracture the protective coating, making the methionine molecule vulnerable to rumen degradation.
This labor intensive practice, however, does not allow the ingredient to be uniformly distributed in the diet.
As a result, cows within a herd may consume different amounts of methionine.
Previous attempts to implement this technology, however, were met with unpredictable milk production responses.
Because the two ingredients are combined in a predetermined ratio, the product offers less flexibility in formulating a ration which meets a least cost objective and precludes the possibility of formulating a feed ration which includes the hydroxy analog of methionine but not bypass fat.
In addition, the dry form of the product is susceptible to the formation of undesirable dust and to non-uniform mixing with other feed ration ingredients.

Method used

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  • Process for optimizing milk production
  • Process for optimizing milk production
  • Process for optimizing milk production

Examples

Experimental program
Comparison scheme
Effect test

example 1

Objective:

To determine the rumen bypass and gastrointestinal availability of HMB (DL, 2-hydroxy-4-[methylthio]butanoic acid) and the response of serum methionine to HMB supplementation in lactating dairy cows.

Experimental Procedures

The absorption and metabolism of 2-hydroxy-4-[methylthio]butanoic acid sold by Novus International (St. Louis, Mo. under the Alimet® was measured in four lactating dairy cows fitted with rumen and duodenal T-type cannulae (10 cm distal to the pylorus). The cows were offered a basal diet of barley-based concentrate (Table I) and alfalfa hay. The concentrate was fed at a level of 1 kg for every 2.5 kg of milk produced (Table I) and access to alfalfa hay was ad libitum. In addition, cows received 30 g HMB mixed with 2 kg ground corn grain per day for six days to allow for adaptation of the rumen microflora. Cows were then fed 90 g HMB mixed with the ground corn and were administered 600 ml chromium-EDTA (3 g Cr) (Binnerts et al., “Soluble chromium ind...

example 2

In a lactation study, the effects of providing Alimet® (2-hydroxy-4-[methylthio]butanoic acid sold by Novus International (St. Louis, Mo.)) feed supplement in the close-up pre-lactation dry period and in early lactation diets was evaluated. The diets (Table IV) were formulated to include Alimet® to meet the methionine requirements as determined using existing computer modeling technology (CNCPS and DAIRYLP). The diets were balanced to meet amino acid requirements and included standard feed ingredients used in dairy rations. In the absence of added Alimet®, the control diet was predicted to be first limiting in methionine. The estimated need for methionine was approximately 9 grams per day. Alimet® was added assuming an availability to the ruminant of 20%.

This study included 10 multiparous and five primiparous cows per treatment, supplemented with Alimet® for two weeks before calving and for 12 weeks of lactation. The Alimet® treatment group produced more milk (33.9 vs 31.3 kg / d; ...

example 3

In a field trial, Alimet® (2-hydroxy-4-[methylthio]butanoic acid sold by Novus International (St. Louis, Mo.) at a 40% bypass estimate) was fed to 75 high producing early lactation cows as part of their diet. The Cornell Net Carbohydrate Net Protein Model was used to evaluate the diet (corn grain based diet) being fed to these cattle. The ration being fed was balanced for 90 pounds of 3.7% butterfat milk per cow per day. In the absence of added Alimet®, the diet was predicted to be first limiting in methionine.

Seventy five multiparous cows were used in each group. The cows were housed in either side of a modern, well ventilated free stall barn. Cattle were allocated to treatment by calving date. As cows calved they were alternately placed in the Alimet® group or a group fed the same commercial TMR without Alimet®. This commercial TMR represents the standard TMR fed in the field at commercial dairies at that time. Milk production of each cow was measured at every milking until 75 ...

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Abstract

A method of supplying a ruminant with its nutritional requirements for methionine is provided wherein an ester of 2-hydroxy-4(methylthio)butanoic acid that is available for absorption by a ruminant is administered to the ruminant. Preferably, the ruminant is administered an ester of 2-hydroxy-4(methylthio)butanoic acid is selected from the group consisting of methyl, ethyl, butyl, and 3-methylbutyl, and salts thereof.

Description

BACKGROUND OF THE INVENTION The present invention generally relates to a process for satisfying the nutritional requirements of ruminants for methionine, and more specifically, to a process for meeting those nutritional requirements using the hydroxy analog of methionine (2-hydroxy-4(methylthio)butanoic acid) and its salts, amides and esters. High producing dairy cows need methionine, lysine and other key essential amino acids to reach their genetic potential for milk production. While amino acids can be added directly to the diets of monogastric animals to overcome nutritional deficiencies, free amino acids are rapidly degraded by rumen bacteria and are of little or no practical benefit in alleviating amino acid deficiencies in ruminants. Traditionally, undegradable intake protein (“UIP”) such as blood meal, fish meal, corn gluten meal and others have been used to provide essential amino acids to ruminants. It is difficult, however, to accurately deliver needed levels of methion...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A23K1/16A23K1/18
CPCA23K1/1609Y10S426/807A23K1/1813A23K1/1634A23K20/105A23K20/142A23K50/10
Inventor KNIGHT, CHRISTOPHER D.KOENIG, KAREN M.RODEVANDENBERG, MICHAEL J.VAZQUEZ-ANON, MERCEDES
Owner NOVUS INTERNATIONAL INC