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Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins and uses thereof

a technology of human transporter protein and nucleic acid molecule, which is applied in the field of isolated human transporter protein and human transporter protein, can solve the problems of insufficient sequence similarity, insufficient homology between these two families, and insufficient evidence of such a function

Inactive Publication Date: 2005-06-23
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0052]FIG. 2 provides the predicted amino acid sequence of the transporter of the present invention. In addition structure and functional information such as protein

Problems solved by technology

These families include a member or members for which a transport function has been suggested, but evidence for such a function is not yet compelling.
However, homology between these two families cannot be established on the basis of sequence comparisons alone.
The P domains of IRK channels exhibit limited sequence similarity to those of the VIC family, but this sequence similarity is insufficient to establish homology.

Method used

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  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins and uses thereof
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins and uses thereof
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins and uses thereof

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specific embodiments

Peptide Molecules

[0056] The present invention provides nucleic acid sequences that encode protein molecules that have been identified as being members of the transporter family of proteins and are related to the sodium bicarbonate cotransporter subfamily (protein sequences are provided in FIG. 2, transcript / cDNA sequences are provided in FIGS. 1 and genomic sequences are provided in FIG. 3). The peptide sequences provided in FIG. 2, as well as the obvious variants described herein, particularly allelic variants as identified herein and using the information in FIG. 3, will be referred herein as the transporter peptides of the present invention, transporter peptides, or peptides / proteins of the present invention.

[0057] The present invention provides isolated peptide and protein molecules that consist of, consist essentially of, or comprising the amino acid sequences of the transporter peptides disclosed in the FIG. 2, (encoded by the nucleic acid molecule shown in FIG. 1, transcrip...

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Abstract

The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.

Description

FIELD OF THE INVENTION [0001] The present invention is in the field of transporter proteins that are related to the sodium bicarbonate cotransporter subfamily, recombinant DNA molecules, and protein production. The present invention specifically provides novel peptides and proteins that effect ligand transport and nucleic acid molecules encoding such peptide and protein molecules, all of which are useful in the development of human therapeutics and diagnostic compositions and methods. BACKGROUND OF THE INVENTION Transporters [0002] Transporter proteins regulate many different functions of a cell, including cell proliferation, differentiation, and signaling processes, by regulating the flow of molecules such as ions and macromolecules, into and out of cells. Transporters are found in the plasma membranes of virtually every cell in eukaryotic organisms. Transporters mediate a variety of cellular functions including regulation of membrane potentials and absorption and secretion of mole...

Claims

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Application Information

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IPC IPC(8): A01K67/033A61K45/00A61P43/00A01K67/027C07K14/47C07K14/705C07K16/28C12M1/00C12M1/34C12N1/15C12N1/19C12N1/21C12N5/10C12N15/09C12N15/12C12P21/02C12Q1/02C12Q1/68G01N33/15G01N33/50G01N33/53G01N33/68
CPCA01K2217/05C07K14/47C07K2319/00G01N2500/04C12Q1/6883G01N33/6872G01N2333/47C12N2799/021A61P43/00
Inventor WEI, MING-HUILI, JIAYINGONG, FANGCHENGGABRIELIAN, ANDREIKETCHUM, KARENDI FRANCESCO, VALENTINABEASLEY, ELLEN
Owner APPLERA