Compounds and methods for increasing neurogenesis

a neurogenesis and compound technology, applied in the field of compound and method for increasing neurogenesis, can solve the problems of limited fetal tissue grafting, small factors known to affect neurogenesis in vivo, and limited donor tissue, so as to increase the number of adult neural stem cells in the patient, and reduce at least one symptom of the disorder
US20050209142A1Inactive Publication Date: 2005-09-22NEURONOVA AB COMPANY REGISTRATION NO 556703 0118
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
NEURONOVA AB COMPANY REGISTRATION NO 556703 0118
Publication Date
2005-09-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis modulating agents. Novel methods for treating neurological disorders using neurogenesis modulating agents are disclosed.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation-in-part of application Ser. No. 10 / 850,055 filed May 19, 2004, which is a continuation-in-part of application Ser. No. 10 / 718,071 filed Nov. 20, 2003, which claim the benefit of provisional Application No. 60 / 427,912 filed Nov. 20, 2002. All patents and patent applications cited in this disclosure are hereby incorporated by reference.FIELD OF THE INVENTION

[0002] The invention is directed to in vitro and in vivo methods of modulating neurogenesis. Novel agents for modulating neurogenesis and novel Exendin analogs also provided. BACKGROUND OF THE INVENTION

[0003] Neural stem cells (NSC) are a source for new neurons in the mammalian CNS. NSC are located within the ependymal and / or subventricular zone (SVZ) lining the lateral ventricle (Doetsch et al., 1999; Johansson et al., 1999b) and in the dentate gyrus of the hippocampal formation (Gage et al., 1998). Studies have revealed the potential for several additional locations...

Claims

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