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Nanoparticulate megestrol formulations

a technology of megestrol and nanoparticulate, which is applied in the direction of drug compositions, dispersed delivery, sexual disorders, etc., can solve the problems of unsatisfactory delivery system, high viscosity substances are not well accepted by patient populations, and relative long residence time, so as to improve physical (viscosity) and pharmacokinetic profiles, the effect of less variability

Inactive Publication Date: 2005-10-20
ALKERMES PHARMA IRELAND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017] Finally, the present invention is directed to megestrol acetate compositions with improved physical (viscosity) and pharmacokinetic profiles (such as less variability) over traditional forms of megestrol acetate.

Problems solved by technology

The commercial formulations of megestrol acetate are highly viscous suspensions, which have a relatively long residence time in the mouth and any tubing.
Highly viscous substances are not well accepted by patient populations, particularly patients suffering wasting and those that are intubated.
Such a delivery system can be undesirable, as “breaking down” an active agent's crystalline structure can modify the activity of the active agent.

Method used

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  • Nanoparticulate megestrol formulations

Examples

Experimental program
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Effect test

example 1

[0187] The purpose of this example was to describe preparation of nanoparticulate dispersions of megestrol acetate.

[0188] Formulations 1, 2, 3, 4 and 5, shown in Table 1, were milled under high energy milling conditions using a NanoMill® (Elan Drug Delivery, Inc.) (see e.g., WO 00 / 72973 for “Small-Scale Mill and Method Thereof”) and a Dyno®-Mill (Willy Bachofen AG).

TABLE 1IdentityIdentity andandQuantityQuantityQuantityof Primaryof SecondaryofSurfaceSurfaceMeanD90FormulationMegestrolStabilizerStabilizer(nm)(nm)15%1% HPC-SL0.05% DOSS16722425%1% HPMC0.05% DOSS15621535%1% PVP0.05% DOSS16722645%1% Plasdone ®0.05% DOSS164222S630*55%1% HPMC0.05% SLS148208

*Plasdone ® S630 (ISP) is a random copolymer of vinyl acetate and vinyl pyrrolidone.

[0189] Formulations 1-5 showed small, well-dispersed particles using the Horiba La-910 Laser Scattering Particle Size Distribution Analyzer (Horiba Instruments, Irvine, Calif.) and light microscopy. Formulations 1-5 were stable in electrolyte fluids and...

example 2

[0190] This example compares the pharmacokinetic parameters of nanoparticulate megestrol acetate formulations of the present invention with conventional microparticulate formulations of megestrol acetate.

[0191] Twelve male beagles, at least twelve months of age, were divided into 2 groups based on whether they were fasting or being fed. The dogs were acclimated for thirteen days prior to dosing. The animals weighed approximately 11.4 to 14.3 kg at the time of dosing, and the dose was adjusted to 10 mg / kg. Water was available ad libitum. The animals were fasted (food only) for twelve to sixteen hours prior to dosing on day 1. On day 1, each dog was administered a formulation by gavage. Following dosing, the gavage tube was flushed with 18 ml of water. In the fed study, the animals were fed a high fat meal about 1 hour prior to dosing.

[0192] The dogs were subdivided into four groups, with each group receiving either Formulation-A (nanoparticulate megestrol dispersion #1, comprising ...

example 3

[0199] This example demonstrates the physical stability of megestrol acetate dispersions at various concentrations and with the addition of sucrose, flavoring, and preservatives.

[0200] Megestrol acetate was milled under high energy milling conditions using a NanoMill™2 System (Elan Drug Delivery, Inc.) in the presence of a preservative / buffer system consisting of sodium benzoate, citric acid monohydrate, and sodium citrate dihydrate. After milling, the resulting dispersion was diluted with water, sucrose, flavoring, and additional preservative / buffer to prepare dispersions containing 3% (w / w), 5% (w / w), or 9% (w / w) megestrol acetate. The resulting formulations are shown in Table 4. The physical stability of the formulations was then monitored at 25° C., 40° C., and 50° C.

TABLE 4Formulation SummaryConcentratedDiluted, Flavored DispersionsNanoparticleFormulation EFormulation FFormulation GDispersion3% Dispersion5% Dispersion9% DispersionAPI and Excipientsg / kgg / kgg / kgg / kgMegestrol A...

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Abstract

The present invention is directed to nanoparticulate compositions comprising megestrol. The megestrol particles of the composition have an effective average particle size of less than about 2000 nm.

Description

[0001] This application is a continuation-in-part of application Ser. No. 10 / 412,669 filed Apr. 14, 2003, which claims the priority benefit of U.S. provisional patent application Ser. No. 60 / 371,680, filed Apr. 12, 2002, and U.S. provisional patent application No. 60 / 430,348, filed Dec. 3, 2002.FIELD OF THE INVENTION [0002] The present invention relates to a nanoparticulate composition comprising megestrol and preferably at least one surface stabilizer associated with the surface of the drug. The nanoparticulate megestrol particles have an effective average particle size of less than about 2000 nm. BACKGROUND OF THE INVENTION A. Background Regarding Nanoparticulate Compositions [0003] Nanoparticulate compositions, first described in U.S. Pat. No. 5,145,684 (“the '684 patent”), are particles consisting of a poorly soluble therapeutic or diagnostic agent having adsorbed onto the surface thereof a non-crosslinked surface stabilizer. The '684 patent does not describe nanoparticulate co...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/00A61K9/10A61K9/14A61K31/57A61K45/06A61K47/20A61K47/32A61K47/38
CPCA61K9/0095A61K9/5169A61K9/145A61K9/146A61K31/57A61K45/06A61K47/20A61K47/32A61K47/38A61K9/10A61K9/5161A61K9/08A61K9/14A61K31/573A61K47/34A61K47/26A61K47/42A61K9/5123A61K9/5138A61K2300/00A61P15/18A61P35/00A61P5/24
Inventor HOVEY, DOUGLASPRUITT, JOHNRYDE, TUULA
Owner ALKERMES PHARMA IRELAND LTD
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