Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methods and systems for treating restenosis sites using electroporation

a technology of electroporation and restnosis, applied in the field of electroporation, can solve the problems of inability to closely monitor and control

Inactive Publication Date: 2006-12-28
ANGIODYNAMICS INC
View PDF28 Cites 113 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0020] Accordingly, an object of the present invention is to provide improved systems and methods for treating restenosis sites using electroporation.
[0021] Another object of the present invention is to provide systems and method for treating restenosis sites using electroporation using sufficient electrical pulses to induce electroporation of cells in the restenosis site, without creating a thermal damage effect to a majority of the restenosis site.

Problems solved by technology

However, when used deep in the body, as opposed to the outer surface or in the vicinity of the outer surface of the body, it has a drawback that is typical to all minimally invasive surgical techniques that occur deep in the body, it cannot be closely monitored and controlled.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods and systems for treating restenosis sites using electroporation
  • Methods and systems for treating restenosis sites using electroporation
  • Methods and systems for treating restenosis sites using electroporation

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0082] An area of the restenosis tissue site is imaged. A catheter 34, with the electroporation balloon 36 and two mono-polar electrodes 12, is introduced through the vasculature of a patient. The electroporation balloon 36 is positioned at the restenosis tissue site. Imaging is used to confirm that the mono-polar electrodes are properly placed. Pulses are applied with a duration of 5 microseconds to about 62 seconds each. Monitoring is preformed using ultrasound. The restenosis tissue site is monitored. In response to the monitoring, pulses are adjusted to maintain a temperature of no more than 100 degrees C. A voltage gradient at the restenosis tissue site in a range of from about 50 volt / cm to about 1000 volt / cm is created. A volume of the restenosis tissue site undergoes cell necrosis.

example 2

[0083] An area of the restenosis tissue site is imaged. A catheter 34, with the electroporation balloon 36 and a bipolar electrode 14 is introduced through the vasculature of a patient. The electroporation balloon 36 is positioned at the restenosis tissue site. Imaging is used to confirm that the electroporation balloon 36 is properly placed. Pulses are applied with a duration of about 90 to 110 microseconds each. Monitoring is performed using a CT scan. The restenosis tissue site is monitored. In response to the monitoring, pulses are adjusted to maintain a temperature of no more than 75 degrees C. A voltage gradient at the restenosis site in a range of from about 50 volt / cm to about 5000 volt / cm is created. A volume of the restenosis tissue site undergoes cell necrosis.

example 3

[0084] An area of the restenosis tissue site is imaged. A catheter 34, with the electroporation balloon 36 and a band 20 of mono-polar electrodes is introduced through the vasculature of a patient. The electroporation balloon 36 is positioned at the restenosis tissue site. Imaging is used to confirm that the mono-polar electrodes are properly placed. Pulses are applied with a duration of about 100 microseconds each. A monitoring electrode 18 is utilized. Prior to the full electroporation pulse being delivered a test pulse is delivered that is about 10% of the proposed full electroporation pulse. The test pulse does not cause irreversible electroporation. The restenosis tissue site is monitored. In response to the monitoring, pulses are adjusted to maintain a temperature of no more than 60 degrees C. A voltage gradient at the restenosis site in a range of from about 50 volt / cm to about 8000 volt / cm is created. A volume of the restenosis tissue site undergoes cell necrosis.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A system is provided for reducing restenosis. A catheter apparatus is provided with at least first and second mono-polar electrodes positioned at an inflatable balloon. The balloon is sized to be positioned and expanded at a restenosis site. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply an electric field, in a controlled manner, to the restenosis site in an amount sufficient to produce electroporation of the restenosis site, and below an amount that causes thermal damage to the restenosis site.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is related to U.S. Ser. No. ______ (Atty Docket 42218-0002), Ser. No. ______ (Atty Docket 42218-0004), and Ser. No. ______ (Atty Docket 42218-0005), filed on the same date as the instant application, all of which applications are fully incorporated herein by reference.BACKGROUNDI [0002] 1. Field of the Invention [0003] This invention relates generally to electroporation, and more particularly to systems and methods for treating restenosis sites of a patient using electroporation. [0004] 2. Description of the Related Art [0005] Electroporation is defined as the phenomenon that makes cell membranes permeable by exposing them to certain electric pulses (Weaver, J. C. and Y. A. Chizmadzhev, Theory of electroporation: a review. Bioelectrochem. Bioenerg., 1996. 41: p. 135-60). The permeabilization of the membrane can be reversible or irreversible as a function of the electrical parameters used. In reversible electroporation t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61F7/00
CPCA61B18/1492A61B2017/22002A61B2018/00422A61B2018/0022A61B2018/00214A61B2018/00613
Inventor RUBINSKY, BORISONIK, GARYMIKUS, PAUL
Owner ANGIODYNAMICS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com