Methods and systems for treating restenosis sites using electroporation

a technology of electroporation and restnosis, applied in the field of electroporation, can solve the problems of inability to closely monitor and control

Inactive Publication Date: 2006-12-28
ANGIODYNAMICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0028] Still a further object of the present invention is to provide systems and methods for treating restenosis sites using electroporation that is performed in a controlled manner to provide for controlled pore formation in cell membranes.
[0029] Still an...

Problems solved by technology

However, when used deep in the body, as opposed to the outer surface or in the vicinity of the outer surface of the body, it has a draw...

Method used

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  • Methods and systems for treating restenosis sites using electroporation
  • Methods and systems for treating restenosis sites using electroporation
  • Methods and systems for treating restenosis sites using electroporation

Examples

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Effect test

example 1

[0082] An area of the restenosis tissue site is imaged. A catheter 34, with the electroporation balloon 36 and two mono-polar electrodes 12, is introduced through the vasculature of a patient. The electroporation balloon 36 is positioned at the restenosis tissue site. Imaging is used to confirm that the mono-polar electrodes are properly placed. Pulses are applied with a duration of 5 microseconds to about 62 seconds each. Monitoring is preformed using ultrasound. The restenosis tissue site is monitored. In response to the monitoring, pulses are adjusted to maintain a temperature of no more than 100 degrees C. A voltage gradient at the restenosis tissue site in a range of from about 50 volt / cm to about 1000 volt / cm is created. A volume of the restenosis tissue site undergoes cell necrosis.

example 2

[0083] An area of the restenosis tissue site is imaged. A catheter 34, with the electroporation balloon 36 and a bipolar electrode 14 is introduced through the vasculature of a patient. The electroporation balloon 36 is positioned at the restenosis tissue site. Imaging is used to confirm that the electroporation balloon 36 is properly placed. Pulses are applied with a duration of about 90 to 110 microseconds each. Monitoring is performed using a CT scan. The restenosis tissue site is monitored. In response to the monitoring, pulses are adjusted to maintain a temperature of no more than 75 degrees C. A voltage gradient at the restenosis site in a range of from about 50 volt / cm to about 5000 volt / cm is created. A volume of the restenosis tissue site undergoes cell necrosis.

example 3

[0084] An area of the restenosis tissue site is imaged. A catheter 34, with the electroporation balloon 36 and a band 20 of mono-polar electrodes is introduced through the vasculature of a patient. The electroporation balloon 36 is positioned at the restenosis tissue site. Imaging is used to confirm that the mono-polar electrodes are properly placed. Pulses are applied with a duration of about 100 microseconds each. A monitoring electrode 18 is utilized. Prior to the full electroporation pulse being delivered a test pulse is delivered that is about 10% of the proposed full electroporation pulse. The test pulse does not cause irreversible electroporation. The restenosis tissue site is monitored. In response to the monitoring, pulses are adjusted to maintain a temperature of no more than 60 degrees C. A voltage gradient at the restenosis site in a range of from about 50 volt / cm to about 8000 volt / cm is created. A volume of the restenosis tissue site undergoes cell necrosis.

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PUM

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Abstract

A system is provided for reducing restenosis. A catheter apparatus is provided with at least first and second mono-polar electrodes positioned at an inflatable balloon. The balloon is sized to be positioned and expanded at a restenosis site. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply an electric field, in a controlled manner, to the restenosis site in an amount sufficient to produce electroporation of the restenosis site, and below an amount that causes thermal damage to the restenosis site.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is related to U.S. Ser. No. ______ (Atty Docket 42218-0002), Ser. No. ______ (Atty Docket 42218-0004), and Ser. No. ______ (Atty Docket 42218-0005), filed on the same date as the instant application, all of which applications are fully incorporated herein by reference.BACKGROUNDI [0002] 1. Field of the Invention [0003] This invention relates generally to electroporation, and more particularly to systems and methods for treating restenosis sites of a patient using electroporation. [0004] 2. Description of the Related Art [0005] Electroporation is defined as the phenomenon that makes cell membranes permeable by exposing them to certain electric pulses (Weaver, J. C. and Y. A. Chizmadzhev, Theory of electroporation: a review. Bioelectrochem. Bioenerg., 1996. 41: p. 135-60). The permeabilization of the membrane can be reversible or irreversible as a function of the electrical parameters used. In reversible electroporation t...

Claims

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Application Information

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IPC IPC(8): A61F7/00
CPCA61B18/1492A61B2017/22002A61B2018/00422A61B2018/0022A61B2018/00214A61B2018/00613
Inventor RUBINSKY, BORISONIK, GARYMIKUS, PAUL
Owner ANGIODYNAMICS INC
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