Intracoronary device and method of use thereof

a technology of intracoronary devices and therapeutic cells, which is applied in the direction of cardiovascular disorders, drug compositions, peptides, etc., can solve the problems of limited engraftment, limited therapeutic potential, and inability to attach therapeutic cells, so as to improve the migratory function, enhance the adhesion probability, and increase the residence time

Inactive Publication Date: 2007-01-04
ABBOTT CARDIOVASCULAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0004] Various embodiments of the present subject matter provide enhanced migratory function, enhanced adhesion probability, increased residence time (for example longer residence time of the therapeutic cell in the coronary arte

Problems solved by technology

Those therapeutic cells that fail to attach provide no benefit.
The inability of such cells to migrate may

Method used

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  • Intracoronary device and method of use thereof
  • Intracoronary device and method of use thereof
  • Intracoronary device and method of use thereof

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Embodiment Construction

[0034] Reference will now be made in detail to certain claims of the invention, examples of which are illustrated in the accompanying text and examples. While the invention will be described in conjunction with the enumerated claims, it will be understood that they are not intended to limit the invention to those claims. On the contrary, the invention is intended to cover all alternatives, modifications, and equivalents, which may be included within the scope of the present invention as defined by the claims.

I. DEFINITIONS

[0035] An “engraftment enhancing agent” is defined herein as an agent or process of cellular manipulation that promotes, improves or enhances cellular engraftment of a therapeutic cell at a target site, for example, an agent that enhances the incorporation, i.e., adherence and / or transmigration, of a therapeutic cell in an area of infarcted myocardium. A process of cellular manipulation that enhances the incorporation of a therapeutic cell in a target site includ...

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Abstract

Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

Description

TECHNICAL FIELD [0001] This document relates generally to delivery of therapeutic cells to a target site of a mammal and in particular, to a method and apparatus for enhancing engraftment at the target site. BACKGROUND OF THE INVENTION [0002] Damaged tissue, such as a lesion in a vessel, can be treated with therapeutic cells. For example, therapeutic cells can be injected into the vasculature to treat a lesion in the vessel. Some therapeutic cells will attach to the target site and provide treatment to the damaged tissue. However, depending on factors such as the dimensions of the target site, some of the therapeutic cells will flow past the lesion site without attaching to the site. Those therapeutic cells that fail to attach provide no benefit. Moreover, it has been reported that autologous bone marrow cells isolated from patients with chronic heart failure have “significantly reduced migratory and colony forming activity in vitro and a reduced neovascularization capacity in vivo”...

Claims

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Application Information

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IPC IPC(8): A61K35/12A61K38/19A61K38/18C12N5/08A61K35/545
CPCA61K38/19A61K38/18A61K35/545A61K2300/00A61P41/00A61P43/00A61P9/00
Inventor CONSIGNY, PAULASONGWE, GABRIELMICHAELS, MARY BETHMICHAL, GENEMANDRUSOV, EVGENIALEE, JEONGLUDWING, FLORIANHENCKEL, JOHN ERICSCIACCA, JOSEPH J.BUECHE, KENTHORNTON, RICHARD TODDURRABAZO, FIDEL ALBERTWIEGAND, DANIEL
Owner ABBOTT CARDIOVASCULAR
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