Compositions and methods for treating acne

Inactive Publication Date: 2007-03-01
REVANCE THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017] This invention provides methods and kits for treating acne, especially severe cases of acne. The invention involves using a vasoconstricting agent in conjunction with an anti-acne agent to treat acne lesions. In preferred embodiments, the vasoconstricting agent is applied prior to the anti-acne agent, and serves to reduce the outflow of anti-acne agent from the

Problems solved by technology

Sebum which normally drains to the surface gets blocked and bacteria begin to grow.
Blackheads can often take a long time to clear because the contents very slowly drain to the surface.
Nodular acne consists of acne spots which are much larger, can be quite painful, and can sometimes last for months.
They can be painful and scarring is common with cystic acne.
The redness is often accompanied by bumps, pimples, and skin blemishes.
Left untreated, it can cause swelling of the nose and the growth of excess tissue, a condition called

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Two-Step Acne Treatment

[0042] This example provides a two step treatment for acne. The first step involves topically applying a vasoconstricting composition to the acne lesion to be treated. Suitable vasoconstricting compositions include tetrahydrozoline HCl 0.05%, naphazoline HCl 0.03%, or oxymetazoline HCl 0.025% in an aqueous base containing HPC to increase the viscosity for ease of application. Upon application of the vasoconstricting composition, the redness and swelling of the acne lesion diminishes, making the acne lesion less noticeable. After about 5 minutes, a second step is performed which involves topically applying 5% benzoyl peroxide 5% in an oil-in water moisturizer base. In this example, the benzoyl peroxide 5% is tinted to match the skin tone of the user, but this tinting is optional. Within two days, the acne lesion has healed substantially.

example 2

Three-Step Acne Treatment for Nighttime Use

[0043] This example provides a three-step nighttime treatment for acne. The first step involves topically applying a vasoconstricting composition to the acne lesion to be treated. Suitable vasoconstricting compositions include tetrahydrozoline HCl 0.05%, naphazoline HCl 0.03%, or oxymetazoline HCl 0.025% in an aqueous base containing HPC to increase the viscosity for ease of application. Upon application of the vasoconstricting composition, the redness and swelling of the acne lesion diminishes, making the acne lesion less noticeable. After about 5 minutes, a second step is performed which involves topically applying 5% benzoyl peroxide in an oil-in water moisturizer base. The acne lesion is then covered with a patch that includes silicone on the skin-side of the patch. The patch remains in place overnight and is removed in the morning.

[0044] The following night, the three-step acne treatment is repeated. Noticeable improvement in the acn...

example 3

Three-Step Acne Treatment for Daytime Use

[0045] This example provides a three-step acne treatment that is suitable for daytime use. The first step involves topically applying a vasoconstricting composition to the acne lesion to be treated. Suitable vasoconstricting compositions include tetrahydrozoline HCl 0.05%, naphazoline HCl 0.03%, or oxymetazoline HCl 0.025% in an aqueous base containing HPC to increase the viscosity for ease of application. Upon application of the vasoconstricting composition, the redness and swelling of the acne lesion diminishes, making the acne lesion less noticeable. After about 5 minutes, a second step is performed which involves topically applying 5% benzoyl peroxide in an oil-in-water moisturizer base. Next, a water-in-oil moisturizer is applied to minimize evaporation and to help occlude the area.

[0046] This treatment is repeated twice daily. Significant healing of the acne lesion is noted after two days.

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Abstract

This invention provides anti-acne kits that are useful for treating acne, especially severe cases of acne. The anti-acne kits include a vasoconstrictor and an anti-acne agent, and optionally one or more of a skin lightening therapeutic, a sealing layer, a skin cleanser, an astringent, a skin penetration enhancer, a sunscreen, and nutritional supplements that promote healing of acne lesions. This invention also provides methods for treating acne using a vasoconstrictor in conjunction with an anti-acne agent.

Description

BACKGROUND OF THE INVENTION [0001] Acne is a disease of the sebaceous hair follicles, often called pores. At the base of each hair follicle is a gland called the sebaceous gland, which produces sebum. Sebum is an oily substance that keeps the skin moist and pliable, which under normal circumstances travels along the hair follicle to the surface of the skin. A blemish begins approximately 2-3 weeks before it appears on the skin's surface. As the skin renews itself, the old cells die and slough off. When cells are shed unevenly and clump together with the sebum it forms a plug. Sebum which normally drains to the surface gets blocked and bacteria begin to grow. The rapid growth of the bacteria in combination with the accumulated sebum cause the follicle to enlarge and result in a mild form of acne called comedones, which are non-inflammatory. Both whiteheads and blackheads start out as a “microcomedone” and then become skin blemishes called comedones, either a whitehead or a blackhead....

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K31/60A61K31/522A61K31/192A61K36/534A61K36/48A61K36/28A61K36/13
CPCA61K31/192A61K31/522A61K45/06A61K36/61A61K36/605A61K36/539A61K31/60A61K36/14A61K36/185A61K36/28A61K36/45A61K36/484A61K36/53A61K36/534A61K2300/00A61Q17/04A61Q19/00A61Q19/02A61K8/922A61K8/9761A61K8/9789A61K8/9767A61K8/9794A61P17/00A61P17/02A61P17/10A61P9/00A61K31/4174
Inventor WAUGH, JACOB M.LEE, JANE
Owner REVANCE THERAPEUTICS INC
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