Magnetic nanoscale particle compositions, and therapeutic methods related thereto

a magnetic nanoscale particle and composition technology, applied in the field of targeted magnetic nanotherapy compositions and methods, can solve the problem of not being able to selectively deliver a lethal dose of particles to the cells or pathogens of interest, and achieve the effect of short treatment period and minimal invasion
US20070112339A9Inactive Publication Date: 2007-05-17ASPEN MEDISYS +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ASPEN MEDISYS
Publication Date
2007-05-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy. The disclosed methods may be useful in the treatment of a variety of indications, including cancers, diseases of the immune system, central nervous system and vascular system, and pathogen-borne diseases.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This is a Continuation-in-Part application claiming the benefit of and priority to Non-Provisional application having Ser. No. 10 / 200,082 filed on Jul. 19, 2002, and Provisional Patent Application having Ser. No. 60 / 307,785 filed on Jul. 25, 2001, both of which are incorporated herein by reference.TECHNICAL FIELD

[0002] The present invention relates generally to targeted magnetic nanotherapy compositions and methods, and specifically, to magnetic nanoscale particle compositions that comprise an energy susceptive material that is attached to a target-specific ligand, and therapeutic methods that comprise the administration of such compositions to a patient's body, body part, tissue, or body fluid, and the administration of energy from an energy source, so as to destroy or inactivate the target. BACKGROUND

[0003] The time between the onset of disease in a patient and the conclusion of a successful course of therapy is often unacceptably l...

Claims

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