Amphiphilic polymeric coating

Abstract

The present invention provides an amphiphilic coating material for applying on at least a portion of one surface of an article. The amphiphilic coating material comprises a polymer having a hydrophobic backbone derived from a vinyl moiety and hydrophilic pendent chains derived from a polyethylene oxide moiety. The present invention also provides an article having an amphiphilic coating thereon. The hydrophobic backbone derived from a vinyl moiety adheres to at least one surface of an article. The hydrophilic pendent chains derived from a polyethylene oxide moiety extend from the hydrophobic backbone and form a three-dimensional network.

Description

FIELD OF INVENTION [0001] The present invention relates to an amphiphilic coating material for application to at least a portion of one surface of an article. The present invention also relates to an article having the inventive amphiphilic coating. BACKGROUND OF INVENTION [0002] Most medical devices are made from metals, ceramics, or polymeric materials. However, these materials are hydrophobic, non-conformal, and non-slippery, and thereby may cause injury or inflammation of mucous membranes during use or operation. Thus, the issue of biocompatibility is a critical concern for manufacturers of medical devices, particularly medical implants. In order to function properly and safely, medical devices are usually coated with one or more layers of biocompatible materials. The coatings on these medical devices may, in some instances, be used to deliver therapeutic and pharmaceutical agents. [0003] Since medical devices, particularly implantable medical devices, are intended for prolonged...

AI Technical Summary

Problems solved by technology

However, these materials are hydrophobic, non-conformal, and non-slippery, and thereby may cause injury or inflammation of mucous membranes during use or operation.

However, the preparation of the prior art coating composition employs chemical crosslinking reactions and a high temperature curing process, which are not compatible with a drug-containing coating.

However, the polymer prepared through the plasma process has a poorly defined molecular weight and a large polydispersity.

The plasma laid polymers of low molecular weight have limited mechanical durability.

Further, plasma treatment can penetrate through the underlying basecoat and damage the drug content therein.

Another problem with the prior art approach is that the free radicals or other high energy species generated in the plasma process may persist in the coating and cause drug content loss in the basecoat over time.

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