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Emulsion-based control of electrospun fiber morphology

a technology of electrospun fibers and morphology, applied in the field of emulsion-based control of electrospun fiber morphology, can solve the problems of inability to predict the formation of such fibers, the instability of liquid droplets, and few attempts to alter the geometry of electrospun fibers, so as to achieve the effect of controlling the morphology of fibers

Inactive Publication Date: 2007-06-21
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA +1
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  • Abstract
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  • Application Information

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Benefits of technology

[0014] Inventors have discovered that fiber morphology can be controlled by using multiphasic compositions, such as, for example, a water/oil emulsion or a double emulsion as a fiber-forming medium. The present invention provides a method of making a fiber comprising providing a first component including water, wherein the first component has a first evaporation rate, providing a second component including a polymer dis...

Problems solved by technology

The liquid droplet then becomes unstable and a tiny jet is ejected from the surface of the droplet.
Due to the complexity of the fiber forming process, very few attempts have been made to alter geometry of electrospun fibers.
However, the formation of such fibers is not achievable in a predictable manner under generally known ES operating conditions.
However, there is no suggestion or teaching of how to control the physical characteristics of the tubular product, other than by controlling the charge and rotation speed of the tubular collector.

Method used

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  • Emulsion-based control of electrospun fiber morphology
  • Emulsion-based control of electrospun fiber morphology
  • Emulsion-based control of electrospun fiber morphology

Examples

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example

[0051] As a non-limiting example, the invention will be described based on the effect of a water / oil emulsion on the morphology of poly(L-lactic acid) (PLA) fibers obtained by ES.

[0052] Materials: Poly(L-lactic acid) (MW=300,000) (PLA) was purchased from Polysciences, Inc. (Warrington, PA). Poly(vinyl alcohol) (MW=10,000, 85% hydrolyzed) (PVA) and 1-methyl-2-pyrrolidinone (99.5%) (NMP) were purchased from Aldrich Chemical Co (Milwaukee, Wis.). Chloroform (HPLC grade, 99.8%) was purchased from Fisher Scientific (Pittsburgh, Pa.). Poly(acrylic acid) coated Silica colloids 500 nm in diameter were produced by a sol-gel process. All chemicals were used as received without further purification unless otherwise noted.

[0053] Preparation of Polymer Solutions. Water-in-oil (W / O) emulsion of PLA was prepared by emulsifying a 2% stock of PLA in chloroform with 5% PVA solution in water and a fixed volume of NMP (Table 1). NMP was added to the mixture to serve as a phase compatibilizer (NMP is ...

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Abstract

The invention provides a fiber having different morphology and a method of making such fiber in a predictable manner. The method includes providing a first component including water, wherein the first component has a first evaporation rate, providing a second component including a polymer, wherein the second component has a second evaporation rate, provided that the second evaporation rate is higher than the first evaporation rate, combining the first component and the second component to make an emulsion, applying a force to the emulsion, and extruding the emulsion to make the fiber, wherein the fiber has an outer surface, an internal cavity and a diameter of at most 10 micrometers.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of provisional Application No. 60 / 556,637, filed on Mar. 25, 2004, which is incorporated herein in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This research was supported in part by U.S. Government funds (National Institute of Health, grant number R24-AI47739-03), and the U.S. Government may therefore have certain rights in the invention.BACKGROUND OF THE INVENTION [0003] 1. Field of Invention [0004] This invention relates to a process of making a fiber and more particularly to ways of modifying the fiber's morphology. [0005] 2. Description of Related Art [0006] Electrospinning (ES) is an atomization process of a conducting fluid which exploits the interactions between an electrostatic field and the conducting fluid. During electrospinning, fibers with micron or sub-micron sized diameters are extruded by means of an electrostatic potential from a polymer solutio...

Claims

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Application Information

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IPC IPC(8): D02G3/00D01D5/00D01D5/04D01D5/11D01D5/24D01D5/253D01F1/10D01F6/50D01F6/92D02G3/22
CPCD01D5/0015D01D5/0038D01D5/247Y10T428/2933D01F6/50D01F6/625D01F6/92D01F1/10
Inventor SHASTRI, VENKATRAM P.SY, JAY C.CHEN, I-WEI
Owner THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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