Stable and Water-Soluble Plant Growth Regulator Liquid Compositions and Methods for Use of Same

Abstract

Soluble and stable liquid compositions containing a plant growth regulator selected from the group consisting of cytokinin and a gibberellin, an acid solubilizer such as citric acid, tartaric acid or glycolic acid and a solvent; as well as methods for making and using the composition are disclosed. The compositions improve solubility, handling, stability, safety, as well as activity improvements such as improved plant growth, yield, fruit thinning or sizing and quality. The compositions are soluble and stable by adding an ethoxylated alkyl alcohol wherein the growth regulator is 6-benzyladenine (6-BA) or forchlorfenuron (CPPU) and the ethoxylated alcohol surfactant is C12-15 alkyl alcohol in propylene glycol. The compositions may also contain a cytokinin such as 6-benzyladenine (6-BA) or forchlorfenuron (CPPU) that is increased in solubility and activity and by synergistically combined with GA3 or GA4A7 as well as in storage stability by adding an antioxidant. The compositions are formulated in a ready-to-mix formulation.

Description

FIELD OF THE INVENTION [0001] The present invention is directed to soluble and stable liquid compositions including at least one plant growth regulator, at least one acid solubilizer, at least one surfactant adjuvant, and at least one solvent; as well as methods for making and using the compositions. The soluble liquid composition advantageously improves the preparation, the storage stability, the handler safety and the performance of a plant growth regulator formulation for spray application, as such composition is highly soluble in use dilutions, is easily metered, can be more highly concentrated and is dust-free. A presently preferred soluble liquid composition includes at least one plant growth regulator selected from the group consisting of an adenine cytokinin, an acid solubilizer selected from the group consisting of citric acid, tartaric acid and glycolic acid, a dilution solubilizer comprising a nonionic and / or anionic surfactant blend and a solvent comprising propylene gly...

AI Technical Summary

Benefits of technology

[0018] The present invention is directed to a novel plant growth regulator composition in a concentrated liquid form, as well as methods for making and using the composition. The invention improves a plant growth regulator that is normally insoluble such as 6-benzyladenine (6-BA) or forchlorfenuron (CPPU) by making it more soluble, as well as utilizing its synergistic characteristics by combining it with gibberellins such as GA3 and less stable GA4A7 (GA4+7). The composition comprises at least one plant growth regulator and at least one acid solubilizer selected from the group consisting of citric acid, tartaric acid and glycolic acid. The composition preferably includes at least one solvent and one surfactant. The liquid composition advantageously improves handler safety, preparation, penetration and storage stability of a plant growth regulator formulation for spray application, as such composition swiftly dissolves or is highly soluble, is easily metered, can be more highly concentrated and is dust-free for handling. Preferably the plant growth regulator is selected from the group consisting of gibberellins, auxins, cytokinins, organic acids, ethylene biosynthesis inhibitors, and combinations thereof. More preferably, the plant growth regulator is a cytokinin and / or a gibberelin. Most preferably, the plant growth regulator is 6-benzyl adenine or forchlorfenuron (CPPU).

[0023] The invention is also directed to a method of regulating plant growth comprising the step of treating soil, a seed or a plant with an effective growth-regulating amount of the composition described above. The composition of the present invention may be formulated as a ready-to-mix formulation that is diluted in water and spray-applied in order to improve plant growth, yield, fruit thinning, fruit sizing, flowering and quality. The plant is preferably a fruit bearing plant, as for example one that produces grapes, apples, pears, peaches, cherries, lemons, limes, oranges, pistachio or tangerines.

[0024] The invention is also directed to a method of preparing a soluble liquid plant growth regulator formulation comprising the steps of mixing the plant growth regulator, acid solubilizer, surfactant, antioxidant and solvent to produce a final soluble liquid composition. In the method, preparation of the formulation for spray application can be enhanced, since the solubilizer and the surfactant produce clear spray solution of micro- or nano-particle size and prevent the crystallization of insoluble active ingredient in use dilution, and accurate metering and rapid dissolution of the composition can be attained. The formulation of the present invention is high in product solubility, handling safety, storage stability, and improves plant growth, yield, fruit thinning or sizing and quality. The ready-to-mix compositions can be used for liquid insecticide, herbicide and fungicide formulations.

Problems solved by technology

Each of the conventional types of formulations has disadvantages, so research to provide improved plant growth regulator formulations continues.

Due to diterpenoid structure of gibberellins containing double bonds and cyclic lactone, they are less stable in liquid form, especially in water.

Gibberellin and cytokinin solution formulations are disadvantageous in several respects.

The solutions, such as those of 6-BA in propylene glycol or THFA, are less concentrated due to low solubility of actives, and GA4+A7 have limited stability due to oxidation or chemical degradation.

The result is that current GA4+A7 products have a limited shelf life due to 10-15% loss per year.

Of the currently used solvents, isopropyl alcohol and methyl alcohol offer severe disadvantages such as flammability and toxicity, which lead to restrictions in manufacturing, packaging, labeling, transportation, and warehousing of such solutions.

A more powerful THFA solvent has to be used in some of the 6-BA formulations, however, THFA is considered corrosive to the eye and skin.

Moreover, low solubility of cytokinins in propylene glycol does not permit preparation of high potency solution formulations.

These low strength solution formulations also require larger packaging, more storage space, and higher associated transportation, warehousing, and container disposal costs.

Due to very low solubility and undesirable hydrolysis, it has not been possible to formulate gibberellins or cytokinins in aqueous systems.

The primary disadvantage of wettable powder and soluble powder formulations is that they tend to produce dust upon handling, such as when pouring, transferring or measuring them.

This dust may pose health hazards.

Further, powder formulations tend to wet poorly and also solubilize slowly upon addition to water.

Formation of lumps or partially solubilized spray solutions will lead to uneven distribution of the plant growth regulator in the tank-mix with potential for reduced field performance.

Sometimes, foam in the spray tank caused by spray tank adjuvants can also affect wetting and solubility of wettable and soluble powders.

Wettable powder formulations will also leave undesirable insoluble residues both in the tank and on the sprayed foliage and fruit.

For insoluble cytokinins, the wettable powder formulations of large particle size are ineffective as plant growth regulators.

However, tablets deliver only between 0.1-1 gram of active ingredient per tablet.

They are not ideal for large-scale field operations.

Moreover, effervescent tablets are highly susceptible to humidity, may be slow to dissolve and are expensive.

The quality of water-soluble or water-dispersible granules is highly process- and active-ingredient-dependent, and can result in low yield recoveries, poor attrition resistance leading to dust potential, high manufacturing cost and poor dispersion.

Generally, sprays of dissolved water-dispersible granular formulations leave undesirable insoluble residues on the treated foliage and fruit.

In addition, water-soluble or -dispersible granules can become hardened over time and thus result in poor solubility or dispersibility of the active ingredient.

Dust and caking may be problems with certain water-soluble or water-dispersible granules and powder formulations.

Even with liquid formulations, due to poor water and solvent solubility of plant growth regulators such as 6-benzyl adenine and forchlorfenuron (CPPU), THFA is required to be used as a solvent and precipitation or crystallization of active ingredients can occur in field-tank mixing, which will have an adverse effect on the plant growth regulator activity and the handling of a toxic THFA product.

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