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Wound dressings, apparatus, and methods for controlling severe, life-threatening bleeding

a technology of wound dressings and bandages, applied in the field of advanced hemorrhage control bandages, can solve the problems of no low cost wound dressings that address or any wound dressings, bleeding can be fatal in ballistic injuries, severe arterial lacerations, etc., and achieve the effect of low cost and low cos

Inactive Publication Date: 2008-03-13
PROVIDENCE HEALTH SYST OREGON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The invention is a wound dressing that is designed to control severe bleeding, which is often life-threatening. The dressing is made from a non-mammalian material called chitosan, which is a biomaterial that can be easily obtained and is resistant to dissolution in high blood flow. The dressing has properties that make it effective in controlling bleeding in ballistic injuries and arterial lacerations. It is easy to apply, can quickly clot blood, and is strong enough to withstand rough handling. The dressing is produced from a sponge-like structure that is formed by freezing and then dried to create a sponge-like or woven configuration. Overall, the invention provides a wound dressing that can be used in emergency situations to control bleeding and save lives."

Problems solved by technology

Presently there are no low cost wound dressings that address or any wound dressings that are suitable for control of severe life-threatening bleeding.
Such bleeding can be fatal in ballistic injuries and severe arterial lacerations.

Method used

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  • Wound dressings, apparatus, and methods for controlling severe, life-threatening bleeding
  • Wound dressings, apparatus, and methods for controlling severe, life-threatening bleeding
  • Wound dressings, apparatus, and methods for controlling severe, life-threatening bleeding

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Embodiment Construction

[0073] Table 1 provides a list of the main chitosan materials acquired for hemorrhage control testing. With the exception of the Gelfoam™+thrombin, and Surgicel™ controls for swine spleen experiments and the Johnson and Johnson 4×4 gauze control for use in swine aortic perforations, the dressing materials were all chitosan-based.

[0074] Aqueous solutions (2.00% w / w) were prepared in clean, sterile, 1 liter Pyrex flasks from Ametek UF water and dry chitosan. In the case of the Carbomer, Primex and Genis chitosan materials, 1.0% or 2.0% w / w of glacial acetic acid (Aldrich 99.99%) was added to the aqueous mixtures. Dissolution was achieved by shaking of the flask at 40° C. for 12 to 48 hours. The solutions were degassed by application of vacuum at 500 mTorr at room temperature immediately prior to freezing.

[0075] Wound dressings were prepared from the 2% aqueous solutions of chitosan that were poured into Teflon™ coated aluminum or polystyrene molds to at least 1.5 cm deep and frozen ...

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Abstract

A chitosan biomaterial is frozen in aqueous solution to form a frozen chitosan structure from which water is removed by a prescribed freeze-drying process to form a sponge-like chitosan structure having a thickness and a density. The sponge-like chitosan structure is compressed by application of heat and pressure to reduce the thickness and increase the density of the sponge-like chitosan structure to form a densified chitosan structure. The densified chitosan structure is further preconditioned by heating the densified chitopsan structure according to prescribed conditions to form a wound dressing. The wound dressing possesses an adhesion strength and resistance to dissolution in high blood flow bleeding situations.

Description

RELATED APPLICATIONS [0001] This application is a divisional of co-pending U.S. patent application Ser. No. 10 / 480,827, filed Oct. 6, 2004, which is a United States national stage application designated under 35 U.S.C. §371 of PCT / US02 / 18757, filed Jun. 14, 2002, which claims the benefit of U.S. Provisional Patent Application Ser. No. 60 / 298,773, filed Jun. 12, 2001, which are each incorporated herein by reference.NOTICE [0002] The U.S. Government has a paid-up license in this invention and the right in limited circumstances to license others on reasonable terms as provided by the terms of Grant No. DAMD17-98-1-8654 awarded by the Army / MRMC—Medical Research and Material Command.BACKGROUND OF THE INVENTION [0003] An advanced hemorrhage control bandage and methods of its application would substantially augment available hemostatic methods. To date, the application of continuous pressure with gauze bandage remains the preferred primary intervention technique used to stem blood flow, es...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F13/53A01N43/04A61K38/17A61F13/00A61F13/15A61L15/16A61L15/28A61L15/42A61L33/08
CPCA61F13/00012A61F13/00034A61L2400/04A61F13/00987A61F13/00995A61F13/15203A61F2013/00106A61F2013/00463A61F2013/00468A61F2013/00472A61F2013/00536A61F2013/0054A61F2013/00931A61L15/28A61L15/425C08L5/08A61F13/01034A61F13/01012A61L15/32
Inventor GREGORY, KENTON W.MCCARTHY, SIMON J.
Owner PROVIDENCE HEALTH SYST OREGON
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