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Composition for capsule coating

a technology for coating and capsules, applied in the field of capsule coating, can solve the problems of gelatin falling into disfavor among religious people and vegetarians, gelatin also falling into disfavor, and the production of soft capsules using gelatin as a main component requires heating for a long tim

Inactive Publication Date: 2008-05-15
AJINOMOTO CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013] It is an object of the present invention to provide a capsule shell that can be obtained by mixing (A) vegetable polysaccharide, (B) polyglutamic acid, and (C) water and, where necessary, at least one kind of material selected from (D) a plasticizer, (E) glycerin fatty acid ester and (F) oil.

Problems solved by technology

However, in recent years, gelatin has fallen into disfavor amongst religious people and vegetarians because it is derived from animals.
Gelatin has also fallen into disfavor due to concerns of mad cow disease.
Furthermore, soft capsule production using gelatin as a main component requires heating for a long time from dissolution to during production.
As a result of heating, it is difficult to ensure a constant, reproducible quality for soft capsule production because the heating changes the structure of gelatin thus decreasing the viscosity of liquid, as well as similar structural changes.
However, the use of starch and 1-carageenan in combination as starting materials requires a large amount of water for dissolving the starting materials.
Therefore, drying of the capsule becomes a heavy burden, and the productivity is not entirely good.
However, sufficient strength cannot be achieved during capsule formation due to insufficient of capsule shell sheet adhesiveness during capsule formation.
However, even when combined with a plasticizer such as sorbitol, sufficient adhesiveness cannot be achieved.
In addition, the capsule shell sheet lacks flexibility.
Accordingly, capsule formation is not easy.
However, preparation of a capsule containing PGA requires first drying a capsule shell sheet formed from a shell solution containing PGA over a long time.
Accordingly, problems occur in that capsules cannot be produced continuously, caking occurs when a desiccant is not used during preservation due to the hygroscopicity of the capsule, and the sheet is generally insufficient.

Method used

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  • Composition for capsule coating
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Examples

Experimental program
Comparison scheme
Effect test

examples

Materials and Methods—

[0060] The evaluation methods in the Examples are explained below.

Property Test of Capsule Shell Sheet:

[0061] A 1 mm-thick silicone sheet frame was placed on a 10 cm square PET film, each composition was flown in, and a 10 cm square PET film was placed thereon. This was sandwiched with steel plates and fixed with screws and heated for 5 min in an oil bath to 120° C. to give a capsule shell sheet. The obtained capsule shell sheet was evaluated for adhesiveness, film strength, elongation, and transparency.

Adhesiveness:

[0062] Two test pieces (1 cm×2 cm) were cut out from the capsule shell sheet obtained in the above, placed on one another and adhered with a heat sealer (Fuji Impulse Co., Ltd., P-200). After adhesion, the two pieces of capsule shell sheet were manually peeled off and the adhesiveness was evaluated. According to the dial setting of the heat sealer, the sheet was judged in 4 levels in Table 2. As used herein, adhesion means that the adhered sur...

examples 1-4

[0080] In Examples 1-4, adhesiveness, film strength, elongation and transparency at various ratios of (A) and (B) components were evaluated by the above-mentioned measurement methods. The results are as shown in Table 8.

TABLE 8ParameterEx. 1Ex. 2Ex. 3Ex. 4(A)54%51%48%42%(B) 6% 9%12%18%(C)40%40%40%40%total100% 100% 100% 100% (A) / (A) + (B)90%85%80%70%(B) / (A) + (B)10%15%20%30%adhesiveness◯⊚⊚◯transparency◯◯◯◯strength⊚⊚◯Δelongation◯◯◯◯burden on drying step⊚⊚⊚⊚total evaluation12131210

examples 15-21

[0084] In Examples 15-21, component (D) was increased, component (C) was reduced, and adhesiveness, film strength, elongation and transparency were evaluated by the above-mentioned measurement methods. The results are as shown in Table 11.

TABLE 11ParameterEx. 15Ex. 16Ex. 17Ex. 18Ex. 19Ex. 20Ex. 21(A)45%44%42%39%36%39%40%(B)11%10%10% 9% 9%10%10%(C)41%41%41%40%40%34%32%(D) 4% 5% 8%12%15%17%18%total100% 100% 100%  100% 100% 100% 100% (B) / (A) + (B)19.6%  18.5%  19.2%  18.8%  20.0%  19.4%  20.0%  (D) / (A) + (B)7.1% 9.3% 15.4%  25.0%  33.3%  34.1%  36.0%  adhesiveness◯⊚⊚⊚◯⊚⊚transparencyΔ◯⊚⊚⊚⊚⊚strength⊚⊚⊚◯Δ⊚◯elongation◯◯⊚⊚⊚⊚⊚burden on⊚⊚⊚⊚⊚⊚◯⊚◯drying steptotal11131514121615evaluation

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Abstract

The present invention provides a composition that is suitable for producing a plant-derived, practical capsule shell sheet having both sufficient strength and elongation as a capsule shell, superior adhesiveness and transparency, and a low burden on a drying step. The present invention also provides a capsule shell sheet obtained using the composition and a capsule preparation process. The composition of the present invention contains vegetable polysaccharides and a polyglutamic acid.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] The present application is a continuation of PCT / JP2006 / 311695, filed on Jun. 6, 2006, and claims priority to JP 2005-165652, filed on Jun. 6, 2005, the entire contents of these applications is incorporated herein by reference.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention provides a composition for producing a capsule shell, which comprises (A) a vegetable polysaccharide and (B) polyglutamic acid (sometimes to be referred to as a composition for a capsule shell). The present invention further provides a composition for a capsule shell comprising (A) vegetable polysaccharide, (B) polyglutamic acid, and at least one additional ingredient selected from (C) water, (D) a plasticizer, (E) glycerin fatty acid ester and (F) oil. In addition, the present invention provides a capsule shell sheet and a capsule preparation. [0004] 2. Discussion of the Background [0005] Capsule shells are generally produce...

Claims

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Application Information

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IPC IPC(8): A61K9/48
CPCA23L1/0029A23L1/0522A61K47/36A61K9/4816A61K9/4891A23L1/0562A23P10/30A23L29/212A23L29/281
Inventor SATOKAWA, HIDEOFURUTA, KIYONORIIWASAKI, KEIJI
Owner AJINOMOTO CO INC
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