Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Formulations of Ramipril

a technology of ramipril and stable pharmaceutical formulation, which is applied in the field can solve the problems of complicated preparation of stable pharmaceutical formulation of ramipril

Inactive Publication Date: 2008-09-25
ACTAVIS GRP PTC EHF
View PDF19 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of stable pharmaceutical formulations of ramipril is complicated since it is susceptible to certain types of degradation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Formulations of Ramipril

Examples

Experimental program
Comparison scheme
Effect test

example 1

Formulation for 1.25 mg Ramipril Tablets

[0028]

Ramipril 0.96%Compactrol87.08% w / wSodium hydrogen carbonate 0.96% w / wStarch pregelatinised10.00% w / wSodium stearyl fumarate 1.00% w / w

example 2

Formulation for 2.5 mg, 5 mg and 10 mg Ramipril Tablets

[0029]

Ramipril1.9% w / wCompactrol85.2% w / w Sodium hydrogen carbonate1.9% w / wStarch pregelatinised10.0% w / w Sodium stearyl fumarate1.0% w / w

example 3

Formulation for 2.5 / 12.5 mg and 5 / 25 mg Ramipril Hydrochlorothiazide (HCT) Tablets

[0030]

Ramipril1.9% w / wHydrochlorothiazide9.6% w / wCompactrol70.5% w / w Sodium hydrogen carbonate1.9% w / wStarch pregelatinised15.0% w / w Sodium stearyl fumarate1.0% w / w

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pHaaaaaaaaaa
Compositionsaaaaaaaaaa
stabilityaaaaaaaaaa
Login to View More

Abstract

The present invention relates to stable tablet formulations of ramipril, optionally in combination with a diuretic.

Description

FIELD OF THE INVENTION[0001]The present invention relates to stable pharmaceutical formulations of ramipril, optionally in combination with a diuretic.TECHNICAL BACKGROUND AND PRIOR ART[0002]Ramipril, (2S,3aS,6aS)-1[(S)—N—[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid, 1-ethyl ester is an angiotensin converting enzyme (ACE) inhibitor. Ramipril is used for the treatment of hypertension, heart failure, stroke, myocardial infarction, diabetes and cardiovascular disease.[0003]Ramipril and the acid form, ramiprilat, is described in EP 0 097 022 B1.[0004]The preparation of stable pharmaceutical formulations of ramipril is complicated since it is susceptible to certain types of degradation. Ramipril can undergo cyclization via internal nucleophilic attack to form substituted diketopiperazines and also degrade via hydrolysis and oxidation.[0005]EP 1 501 546 A1 describes stable pharmaceutical formulation for combinations of a statin and an ACE inhibitor....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/403A61K9/20A61K31/401A61K31/549
CPCA61K9/2009A61K9/2059A61K31/00A61K31/407A61K31/549A61K2300/00
Inventor EYJOLFSSON, REYNIR
Owner ACTAVIS GRP PTC EHF
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com