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Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties

a technology of phosphoryl choline acrylate and medical devices, which is applied in the field of organic chemistry, polymer science, material science, and medical devices, can solve the problems of late stent thrombosis, occlusion of conduits, and collapse of intimal flaps or torn arterial linings

Inactive Publication Date: 2008-11-20
ABBOTT CARDIOVASCULAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0052]In an aspect of this invention, the drug reservoir

Problems solved by technology

A problem associated with the PTCA includes the formation of intimal flaps or torn arterial linings which can collapse and occlude the conduit after the balloon is deflated.
However, the use of drug eluting stents (DESs) has resulted in a new problem, late stent thrombosis, the forming of blood clots long after the stent is in place.
The preceding problem has been at least partially ameliorated by the use of increasingly biocompatible materials and / or biocompatible coating.

Method used

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  • Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties
  • Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties
  • Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties

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Embodiment Construction

[0061]Use of the singular herein includes the plural and visa versa unless expressly stated to be otherwise. That is, “a” and “the” refer to one or more of whatever the word modifies. For example, “a therapeutic agent” includes one such agent, two such agents, etc. Likewise, “the layer” may refer to one, two or more layers and “the polymer” may mean one polymer or a plurality of polymers. By the same token, words such as, without limitation, “layers” and “polymers” would refer to one layer or polymer as well as to a plurality of layers or polymers unless, again, it is expressly stated or obvious from the context that such is not intended.

[0062]As used herein, “hydrocarbon” refers to a chemical entity made up entirely of carbon and hydrogen atoms. Hydrocarbons useful for the purposes of this invention include, but are not limited to, saturated or unsaturated, branched or straight-chain aliphatic moieties, saturated or unsaturated cycloaliphatic moieties and aromatic moieties. An alip...

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Abstract

The present invention relates to implantable medical devices coated with phosphoryl choline acrylate polymer topcoat layer, an acrylate copolymer layer containing a therapeutic agent, and their use in the treatment of vascular diseases.

Description

FIELD OF THE INVENTION[0001]This invention relates to the fields of organic chemistry, polymer science, material science and medical devices. In particular, it relates to a medical device having a phosphoryl choline acrylate polymer topcoat layer for treating vascular diseases.BACKGROUND OF THE INVENTION[0002]Percutaneous transluminal coronary angioplasty (PTCA) is a common procedure for treating heart disease. A problem associated with the PTCA includes the formation of intimal flaps or torn arterial linings which can collapse and occlude the conduit after the balloon is deflated. Moreover, thrombosis and restenosis of the artery may develop over several months after the procedure, which may require another angioplasty procedure or a surgical by-pass operation. To reduce the partial or total occlusion of the artery by the collapse of arterial lining, and to reduce the chance of the development of thrombosis and restenosis, a stent is implanted in the lumen to maintain the vascular ...

Claims

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Application Information

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IPC IPC(8): A61F2/06A61K9/00A61P9/00A61P9/10
CPCA61L27/34A61L27/54A61L31/10A61L31/16A61L2300/41A61L2300/416A61L2300/42A61L2300/606A61L2420/08A61P9/00A61P9/10
Inventor PACETTI, STEPHEN D.
Owner ABBOTT CARDIOVASCULAR
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