Accuracy of Continuous Glucose Sensors

a continuous glucose and accuracy technology, applied in the field of continuous glucose monitoring, can solve the problems of separating the portion of bg/cgs error, difficult to accurately and reliably test the accuracy and reliability of cgs devices, and difficult to direct frequent in vivo ig sampling, etc., to improve the accuracy and reliability of cgs and improve the calibration of cgs sensors.

Inactive Publication Date: 2008-12-25
ABBOTT DIABETES CARE INC
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  • Summary
  • Abstract
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  • Claims
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Benefits of technology

[0006]Various objects and advantages of the preferred embodiments of the present invention will be appreciated based on this disclosure. According to the preferred embodiments, the present invention improves the accuracy and reliability of CGS by improving the calibration of CGS sensors or remedying errors due to physiological time lag or a combination thereof.

Problems solved by technology

Most contemporary continuous glucose sensors (hereafter CGS), however, yield blood glucose (hereafter BG) estimates by sampling interstitial glucose (hereafter IG) in interstitial fluid, rather than BG due to the difficulty in directly measuring BG in artery or blood vessels.
As a result, although CGS technology has made dramatic strides, the development of accurate and reliable CGS devices continues to face numerous challenges in terms of calibration, sensitivity, stability, and physiological time lag between blood and interstitial glucose concentrations.
The physiological time lag and gradients are changing dynamically with time, with BG levels, and across subjects; and the direct frequent in vivo sampling of IG is extremely difficult.
Consequently, the evaluation of engineering performance of CGS is left with a central problem: separating the portion of BG / CGS error due to calibration, sensor noise, and BG / IG gradient.

Method used

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  • Accuracy of Continuous Glucose Sensors
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Embodiment Construction

[0029]This invention provides a method and device for improving accuracy of continuous glucose sensors by improving the calibration of the CGS or by remedying errors arising from the physiological time lag between BG and IG, or a combination thereof. In view of many possible variations within the spirit of the invention, the invention will be discussed in the following with reference to specific examples. However, it will be appreciated by those skilled in the art that the following discussion is for demonstration purposes, and should not be interpreted as a limitation. Other variations without departing from the spirit of the invention are also applicable.

[0030]Inaccuracies of most current CGS devices are mainly attributed to poor CGS calibration, physiology time lag, and random errors. To reduce the inaccuracy of the CGS, an improved calibration procedure is proposed. The reduction of inaccuracy can alternatively be achieved by remedying the error related to physiological time lag...

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Abstract

A method, apparatus, and a kit are capable of improving accuracy of CGS devices using dynamic outputs of continuous glucose sensors.

Description

CROSS-REFERENCE TO RELATED PUBLICATIONS[0001]This US patent application claims priority under 35 U.S.C. 119(e) from co-pending U.S. provisional application Ser. No. 60 / 713,203 filed Aug. 31, 2005, and Ser. No. 60 / 815,191 filed Jun. 20, 2006, the subject matter of each being incorporated herein by reference in its entirety. The subject matter of each one of the publications and the US provisional application in APPENDIX A attached herewith is incorporated herein by reference in their entirety.TECHNICAL FIELD OF THE INVENTION[0002]The present invention relates to the art of glucose monitoring, and more particularly to methods and systems for continuous glucose monitoring.BACKGROUND OF THE INVENTION[0003]Existing evidence, such as “National Diabetes Fact Sheet” by American Diabetes Association, indicates that currently approximately 18.2 million people in the U.S. have diabetes; and diabetes is the sixth-leading cause of death in the U.S. One in three Americans born in the year 2000 wi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B19/00
CPCA61B5/14532A61B5/1495A61B5/7203A61B5/7275A61B5/7278
Inventor KOVATCHEV, BORIS P.KING, CHRISTOPHER RYAN
Owner ABBOTT DIABETES CARE INC
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