Perfusion circuit and use therein in targeted delivery of macromolecules
a micromolecule and perfusion circuit technology, applied in the field of perfusion circuits, can solve the problems of heart failure and applicability of gene therapy, and achieve the effects of maximizing safety, minimizing the priming volume of the circuit, and efficient myocyte gene delivery
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[0079]In the following experiments, the inventors compare, using quantitative and histochemical methods, the relative transduction efficiency of a novel method and system of the invention (using cardiopulmonary by-pass, two-way cardiac isolation and retrograde infusion) in the experimental group of animals to a control group in which an equal titer of vector and equal dose of endothelial permeabilizing agent are administered retrograde directly via a catheter in the coronary sinus. Although these studies use an open-chest approach, the control group is designed to simulate what could be achieved using a percutaneous catheter-based transvascular vector delivery technique in a large adult mammal.
[0080]The following experiments are illustrative of the method of the invention, but do not limit the invention.
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[0081]Both the two experimental groups, (n=6, cardiopulmonary by-pass, “CPB”) and (n=1, “PILOT AAV”); and the control group, (n=3, “CATHETER”) consist of normal male canines,...
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