Preparation and applications of novel complexes made by gamma-polyglutamic acid and cisplatin

a technology of polyglutamic acid and complexes, applied in the field of complexes made from gamma-polyglutamic acid and cisplatin, can solve the problems of low yield, high production cost, and limit commercialization
US20090105118A1Inactive Publication Date: 2009-04-23YE HAIFENG +6
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
YE HAIFENG
Publication Date
2009-04-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

A series of complexes made by γ-polyglutamic acid (γ-PGA) and cisplatin, their preparation and applications in biomedical field, specifically in cancer treatment. The complexes may be made by binding free cisplatin on small molecule γ-PGA through the reaction between carboxylic group of γ-PGA and Cl of cisplatin. The complexes show effective anticancer effect and are easy and cost effective to prepare.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a series of complexes made from γ-polyglutamic acid (γ-PGA) and cisplatin, their preparation and applications in biomedical fields, particularly in cancer treatment.BACKGROUND ART

[0002] γ-PGA is a polymer produced by microbial; it can be made by the condensation between the α-amino group and γ-carboxylic group of glutamic acid. γ-PGA was first discovered by Ivanovics et al. (Ivanovics et al., Immunit atsforch. 1937, 90, 304-318) from Bacillus Licheniformis. Subsequently, Bovarnick et al. (Biol Chem. 1942, 145:415) discovered that γ-PGA can be produced by fermentation of some Bacillus Licheniformis. The molecular weight of γ-PGA produced by fermentation ranges between 10 kD and 2000 kD and may be made and separated based on molecular weight ranges for different uses.

[0003] γ-PGA consists of a great number of carboxylic groups and is known to form complexes with certain drugs. The complexes can be metabolized to become glutamic acid ...

Claims

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