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a branching, supportive technology, applied in the field of supporting endoluminal grafts, can solve the problems of compromising the patency of the primary vessel and/or its branches or bifurcations, undisciplined cell development, and rapid development of cellular hyperplasia, and achieve the effect of facilitating good tissue ingrowth
Inactive Publication Date: 2009-05-28
LIFEPORT SCI
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[0010]Another object of the present invention is to provide an improved expandable reinforced graft that is delivered by way of introducers, balloon catheters or similar devices, and which facilitates good tissue ingrowth.
[0011]Another object of this invention is to provide an improved endoluminal graft which fully covers diseased or damaged areas for carrying out luminal repairs or treatments, such as repair of aneurysms.
Problems solved by technology
This runs the risk of compromising the degree of patency of the primary vessel and / or its branches or bifurcation, which may occur as a result of several problems such as displacing diseased tissue, vessel spasm, dissection with or without intimal flaps, thrombosis and embolism.
Stents themselves often do not encourage normal cellular invasion and can lead to undisciplined development of cells in the stent mesh, with rapid development of cellular hyperplasia.
Grafts alone do not provide adequate support in certain instances.
Method used
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Examples
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example i
[0103]This example illustrates the formation of a branched expandable supportive endoluminal graft having an expanded internal diameter of 10 mm and which is bifurcated to accommodate two endoluminal supportive graft legs of 5 to 7 mm in diameter. A liner of non-woven polycarbonate urethane (Corethane®) was spun by winding over a mandrel, generally in accordance with U.S. Pat. No. 4,475,972. In this instance, the liner consisted of approximately 400 layers of fibers. A bifurcated braided mesh tubular supportive component made in a fixture as illustrated in FIG. 26 was spray coated using a dilute solution of polycarbonate urethane having a hardness grade and a melting point lower than that used to spin the liner. It was allowed to dry with warm air. Several spray coats allow for the formation of an adhesive layer.
[0104]The previously prepared polycarbonate urethane liner was cut to length and placed inside the adhesive-coated bifurcated braided mesh and seated to closely fit the bifu...
example ii
[0106]The procedure of Example I is substantially repeated, except the liner is a double tricot polyester mesh net. In a similar arrangement, a trunk component of the same structure was formed, except prior to insertion of the supporting mandrel, a second, innermost liner of polycarbonate urethane is positioned in order to provide a double-lined branched component.
example iii
[0107]The procedures of Example I and of Example II are generally followed, except here the expanded inner diameter of the trunk component is 25 mm, and the cylindrical leg endoluminal grafts are 12-15 mm in diameter.
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Abstract
An endoluminal graft which is both expandable and supportive is provided in a form suitable for use in a branched body vessel location. The graft expands between a first diameter and a second, larger diameter. The support component is an expandable stent endoprosthesis. A liner is applied to the endoprosthesis in the form of a compliant wall material that is porous and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. The supportive endoluminal graft is preferably provided as a plurality of components that are deployed separately at the branching body vessel location, one of which has a longitudinal seam defining leg portions within which the other components fit in a telescoping manner.
Description
CROSS REFERENCE TO RELATED APPLICATION[0001]This is a divisional application of application Ser. No. 09 / 657,041, filed Sep. 5, 2000, which is a reissue application of U.S. Pat. No. 5,855,598 issued Jan. 5, 1999, which is a continuation-in-part of application Ser. No. 08 / 558,028, filed Nov. 13, 1995, filed Nov. 13, 1995, now U.S. Pat. No. 5,632,772 and application Ser. No. 08 / 558,034, filed Nov. 13, 1995, now U.S. Pat. No. 5,639,278, which are each a continuation-in-part of application Ser. No. 140,245, filed Oct. 21, 1993, now abandoned and is related to divisional reissue application Ser. No. 10 / 788,966, filed Feb. 25, 2004, and continuation reissue application Ser. No. 11 / 332,917, filed Jan. 17, 2006.BACKGROUND AND DESCRIPTION OF THE INVENTION[0002]This invention generally relates to supportive endoluminal grafts which have the ability to be delivered transluminally and expanded in place to provide a graft that is endoluminally positioned and placed, with the aid of an appropriate...
Claims
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Patent Type & Authority Applications(United States)
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