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Blood clotting compositions and wound dressings

a composition and blood clotting technology, applied in the field of blood clotting materials and compositions, can solve the problems of insufficient immediate availability of equipment and trained personnel, insufficient stanchment of blood flow, and excessive bleeding, so as to achieve effective coagulation of flowing blood, increase the rate of blood clotting, and easy application to open wounds

Inactive Publication Date: 2009-12-03
TELEFLEX LIFE SCI LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The composition effectively promotes rapid blood clotting with reduced heat transfer to the tissue, making it suitable for traumatic wounds, including those in remote or military settings, with a lower morbidity rate and ease of application, while maintaining product efficacy.

Problems solved by technology

Often bleeding is associated with such wounds.
Unfortunately, however, in other circumstances, substantial bleeding can occur.
If such aid is not readily available, excessive blood loss can occur.
When bleeding is severe, sometimes the immediate availability of equipment and trained personnel is still insufficient to stanch the flow of blood in a timely manner.
Moreover, severe wounds can often be inflicted in very remote areas or in situations, such as on a battlefield, where adequate medical assistance is not immediately available.
Although these materials have been shown to be somewhat successful, they are not effective enough for traumatic wounds and tend to be expensive.
Furthermore, these materials are sometimes ineffective in all situations and can be difficult to apply as well as remove from a wound.
Additionally, or alternatively, they can produce undesirable side effects.
Higher temperatures are sometimes used for LOI calculations, but procedures that utilize these higher temperatures increase the loss of chemical compounds other than water.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Comparison of Supernatant Phase of Zeolite-Reacted Plasma With Serum

[0032]A molecular sieve containing partially re-hydrated zeolite was added to normal pooled plasma. Upon completion of the ensuing reaction, the plasma was separated into two phases, namely, a heavy phase and a supernatant phase. The heavy phase included the typical blood plasma components as well as the reacted zeolite. The supernatant phase was tested to determine the levels of PT, aPTT, and fibrinogen, where “PT” is prothrombin time and “aPTT” is activated partial thromboplastin time. As used herein, PT and aPPT are assays that provide time values that are compared to other samples or to a hemotological standard. The time values are used indirectly to suggest the levels of clotting factors present in pooled plasma. A control comprising serum was also tested to determine the levels of the same components. In a comparison of the supernatant phase to the control, it was noted that the PT, aPTT, and fibrinogen levels...

example 2

Determination of Exothermic Effect of Zeolite-Reacted Plasma

[0033]Varying amounts of a molecular sieve containing zeolite were added to 1 milliliter (ml) samples of normal pooled plasma. In the first sample, 200 milligram (mg) of the molecular sieve was added and reacted, and a temperature increase of 9 centigrade (C.) degrees was observed. In the second sample, about 3.8 mg of the molecular sieve was added and reacted, and a temperature increase of less than 1 C. degree was observed.

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PUM

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Abstract

In general, the basic material forming the wound dressing, covering, and / or application system of the present invention for use in blood coagulation comprises a combination of one or more components selected from the group consisting of clay materials, a molecular sieve material, principally zeolite, and inorganic oxide materials. Although the actual process which enables the wound dressing, covering, and / or application system of the present invention to effectively coagulate flowing blood is unknown, it is believed that the molecular sieve material selectively absorbs small molecules, such as water, from the blood. Due to the absorption of the water molecules, it is believed that the rate of blood clotting is increased.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 10 / 939,869, filed Sep. 13, 2004, which claims the benefit of U.S. Provisional Patent Application No. 60 / 502,571 filed Sep. 12, 2003, entitled “Blood Clotting Compositions and Wound Dressings,” to Francis X. Hursey, the contents of these priority documents are incorporated herein by reference.TECHNICAL FIELD[0002]The present invention relates to blood clotting devices (also referred to as hemostatic agents) and methods of controlling bleeding and, more particularly, to blood clotting materials and compositions for use as bleeding control devices.BACKGROUND OF THE INVENTION[0003]Blood is a liquid tissue that includes red cells, white cells, corpuscles, and platelets dispersed in a liquid phase. The liquid phase is plasma, which includes acids, lipids, solublized electrolytes, and proteins. The proteins are suspended in the liquid phase and can be separated out of the liq...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F13/00A61K33/00A61L26/00
CPCA61K33/00A61L2400/04A61L26/0004
Inventor HURSEY, FRANCIS X.
Owner TELEFLEX LIFE SCI LTD
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