Human antibodies that bind human il-12 and methods for producing

a technology of human antibodies and il-12, which is applied in the field of human antibodies, can solve the problems of eliciting unwanted immune reactions, antibody not described, and limited use of murine il-12 antibodies in vivo
US20110123544A1Inactive Publication Date: 2011-05-26ABBOTT GMBH & CO KG
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ABBOTT GMBH & CO KG
Publication Date
2011-05-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 09 / 534,717, filed Mar. 24, 2000, which issued on Jul. 5, 2005 as U.S. Pat. No. 6,914,128. This application also claims priority to U.S. provisional application Ser. No. 60 / 126,603, filed Mar. 25, 1999. The entire contents of each of the foregoing applications are hereby incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] Human interleukin 12 (IL-12) has recently been characterized as a cytokine with a unique structure and pleiotropic effects (Kobayashi, et al. (1989) J. Exp Med. 170:827-845; Seder, et al. (1993) Proc. Natl. Acad. Sci. 90:10188-10192; Ling, et al. (1995) J. Exp Med. 154:116-127; Podlaski, et al. (1992) Arch. Biochem. Biophys. 294:230-237). IL-12 plays a critical role in the pathology associated with several diseases involving immune and inflammatory responses. A review of IL-12, its biological activities, and its role in disease can be found in Gatel...

Claims

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