Use of strains of lactobacillus and by-products thereof for inhibiting formation of blood vessels
a technology of lactobacillus and by-products, applied in the field of probiotics, can solve the problems of high challenge, achieve the effect of preventing angiogenesis dependant disorders, and reducing or eliminating the risk of occurrence of such disorders
Inactive Publication Date: 2011-06-30
BIO K PLUS INT
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- Application Information
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Benefits of technology
The lactic composition and its supernatant effectively reduce or eliminate the risk of angiogenesis-dependent disorders with minimal side effects, providing a non-invasive and long-term solution that is readily available without the need for prescription, effectively inhibiting capillary formation and cell migration, thus limiting tumour growth.
Problems solved by technology
The challenge is high, since the transformation of normal cells into tumour cells is associated with the acquisition of resistance to most cytotoxic agents presently used in therapy.
Method used
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examples
[0087]The following examples are illustrative of the applicability of the present invention and are not intended to limit its scope. Modifications and variations can be made therein without departing from the spirit and scope of the invention. Although any method and material similar or equivalent to those described herein can be used in the practice for testing of the present invention, the preferred methods and materials are described. The following experimental procedures and materials were used for the examples set fort below
Effects Of Several Supernatants Of Bio-K-Plus Lactic Acid Bacteria On Endothelial Cells Lines
Experimental Approach Used
[0088]1. Effect on the blood capillary network formation;[0089]2. Effect on the endothelial cells migration through blood vessel toward a tumour;[0090]3. Effect of endothelial cells proliferation towards the tumour.
[0091]The following examples are focused on the characterisation of the antiangiogenic properties of lactic acid bacteria compos...
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Abstract
A lactic composition containing at least a bacterial strain selected from the group consisting of Lactobacillus acidophilus, Lactobacillus casei and a mixture of Lactobacillus acidophilus and Lactobacillus casei, and a whole broth of the bacterial strain or the mixture of the bacterial strains, is useful for the prevention or treatment of disorders which are angiogenesis dependant. Both the lactic composition and its supernatant can be used for prevention or treatment of angiogenesis dependant disorders. The supernatant of the lactic composition exhibits antiangiogenic properties.
Description
FIELD OF THE INVENTION[0001]The present invention is related to the field of probiotics useful in the prevention of disorders.BRIEF DESCRIPTION OF THE PRIOR ART[0002]Cancer research aims to discover means by which the aggressive growth of solid tumours and their metastases can be abolished in a specific way without causing treatment resistance, or provoke excessive toxicity in treated patients. The challenge is high, since the transformation of normal cells into tumour cells is associated with the acquisition of resistance to most cytotoxic agents presently used in therapy. Several studies done in the last few years have demonstrated that tumour cells do not represent the only factor responsible for tumour growth. Blood vessels present within these tumours play also a crucial role. It has been clearly established that blood vessels, formed by the angiogenesis process (FIGS. 15 and 16), are essential to aggressive growth of tumours and their metastases. This angiogenesis is due to th...
Claims
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IPC IPC(8): A61K35/74C12N1/20A61P35/00A61P19/02A61P17/06A61P27/02A61P1/04A61K35/00A61K38/00A61K39/02C12Q1/02
CPCA61K35/747A61K38/168A61K38/1709A61K2300/00A61P1/04A61P17/06A61P19/02A61P27/02A61P35/00
Inventor BELIVEAU, RICHARDLUQUET, FRANCOIS-MARIE
Owner BIO K PLUS INT