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Antifungal Treatment

a technology of antifungal treatment and antifungal agent, which is applied in the field of antifungal treatment, can solve the problems of resistance, effective antifungal therapy, and limiting the effectiveness of antifungal therapy

Inactive Publication Date: 2011-12-29
WISCONSIN ALUMNI RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011]In a separate embodiment, the method additionally comprises administering an amount of azole, preferably fluconazole, compound effective to reduce fungal infection.

Problems solved by technology

Toxicity presents one barrier to effective antifungal therapy.
An additional factor limiting the effectiveness of antifungal therapy is resistance.

Method used

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Drk1 Homolog Analysis

[0088]Drk1 homologs were identified from fungal genomes via tBLASTn analysis using the amino acid sequence of Drk1 (GenBank Accession Number: ABF13477). As is indicated below in Table 1, Drk1 is well conserved in pathogens across the Fungal Kingdom. The homolog accession number for each homolog is listed in Table 1. The homologs were individually aligned to Drk1 using NCBI's BLAST alignment tool, and the percent identity, percent similarity, and e-value were recorded. tBLASTn analysis revealed Drk1 homologs in numerous fungal pathogens, including yeast and filamentous organisms.

TABLE 1Histidine Kinase Homologs of Drk1.Accession%%OrganismNumberSimilarityIdentityE-ValueHistoplasma HCEG_05155.2194930Paracoccidioides PAAG_05810.1194890Coccidioides CIMG_04512.386800Penicillium ABAR01000029*, 293880Aspergillus XP_754366294880Candida CLUG_03180.1175600Cryptococcus ABD49452254420Magnaporthe MGG_11174.6176660Ustilago UM02739.1172550Fusarium AAD09491280680Mucor Scaffold 1...

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Abstract

A method of treating or preventing fungal infection, which includes identifying a plant or animal having a fungal infection and administering an effective amount of an anti-fungal composition to the plant or animal to reduce the fungal infection. In a preferred form of the present invention, the antifungal composition is compound 13 or 33 and is combined with an azole compound, such as fluconazole.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Patent Application 61 / 325,548, filed Apr. 19, 2010, which is incorporated herein by reference in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]This invention was made with government support under AI035681 and AI086025 awarded by the National Institutes of Health. The government has certain rights in the invention.BACKGROUND[0003]The incidence of invasive fungal disease has dramatically increased over the past few decades in parallel with the increase in number of immunocompromised patients (J. D. Noshanchuk. Current Status and Future of Antifungal Therapy for Systemic Mycoses. Recent Patents on Anti-Infective Drug Discovery, 2006, 1, 75-84). Patients with increased risk for severe fungal disease include those undergoing administration of broad-spectrum antibiotics, corticosteroids and cytotoxic agents, intravenous catheters, invasive medical procedures, and H...

Claims

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Application Information

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IPC IPC(8): A01N43/824A61K31/433A61K31/4196A01N43/08A01N43/78A61P31/10A01P3/00C07D307/72C07D417/12A61K31/427A61K31/345A01N43/653
CPCA01N43/08C07D417/12A61K31/345A61K31/4196A61K31/427A61K31/433A01N43/82A01N43/653A01N43/78A61K31/341C07D307/66A01N2300/00A61P31/10C07D307/71
Inventor KLEIN, BRUCE STEVENTEBBETS, BRAD MARK
Owner WISCONSIN ALUMNI RES FOUND
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