Treating and preventing microbial infections

Abstract

The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.

Description

SUBMISSION OF SEQUENCE LISTING ON ASCII TEXT FILE[0001]The content of the following submission on ASCII text file is incorporated herein by reference in its entirety: a computer readable form (CRF) of the Sequence Listing (file name: 786212000300SEQLIST.txt, date recorded: Apr. 30, 2018, size: 21 KB).TECHNICAL FIELD[0002]The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid or durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is also particularly useful, for example, for treatment of microbes for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.[0003]The invention also useful for the treatment of path...

AI Technical Summary

Benefits of technology

[0065]For example, the infection is an acute infection. For example, the infection is an acute infection that is rapidly treated. For example, the infection is treated rapidly—for example, the method comprises reducing the infection at least 100-fold by the first 30 minutes (eg, by the first 15 minutes) of the treatment. For example, the treatment is durable—for example, the reduction in infection persists for at least 30 minutes immediately after the first 30 minutes of the treatment. Also, optionally a reduction of the infection by at least 100-fold or 1000-fold is maintained for at least 60 minutes (eg, at least 120 minutes) after commencement of the treatment. Exemplification is provided below which surprisingly demonstrates these, such as a rapid killing that was durable around 3 hours after treatment commenced. For example, the method improves survival of the subject, or improves survival rates in humans or human patients suffering from infection by the microbes of the first species or strain.

Problems solved by technology

This is dangerous because the bacteria and their toxins can be carried through the bloodstream to a subject's entire body.

Septicaemia can quickly become life-threatening.

This inflammation can cause blood clots and block oxygen from reaching vital organs, resulting in organ failure.

Septic shock is fatal in many cases.

Bacteria from these infections enter the bloodstream and multiply rapidly, causing acute infection and immediate symptoms.

People who are already in the hospital for something else, such as a surgery, are at a higher risk of developing septicaemia.

These infections are often more dangerous because the bacteria may already be resistant to antibiotics.

There is a higher risk of developing septicaemia if the subject:has severe wounds or burnsis very young or very oldhas a compromised immune system, which can occur from diseases such as HIV or leukaemiahas a urinary or intravenous catheteris on mechanical ventilationis receiving medical treatments that weakens the immune system, such as chemotherapy or steroid injections

Even in the first stages of the illness, a person can look very sick.

These complications may be fatal if left untreated or if treatment is delayed for too long.

One complication of septicaemia is a serious drop in blood pressure.

Toxins released by the bacteria in the bloodstream can cause extremely low blood flow, which may result in organ or tissue damage.

This is a life-threatening condition that prevents enough oxygen from reaching your lungs and blood.

It often results in some level of permanent lung damage.

It can also damage the brain, which can lead to memory problems.

This leads to widespread inflammation throughout the body.

People with chronic diseases, such as HIV or cancer, are at a higher risk of sepsis.

This is because they have a weakened immune system and cannot fight off the infection on their own.

Sepsis causes millions of deaths globally each year and is the most common cause of death in people who have been hospitalized.

However, combination of antibiotics is not recommended for the treatment of sepsis without shock and in immunocompromised persons unless the combination is used to broaden the anti-bacterial activity.

Neonatal sepsis can be difficult to diagnose as newborns may be asymptomatic.

Acute bacterial infections can, in certain circumstances, be health-threatening or even life-threatening.

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