Methods and materials for assessing loss of heterozygosity

a heterozygosity and heterozygosity technology, applied in the field of methods and materials for assessing the loss of heterozygosity, can solve the problem of serious public health problems such as cancer, and achieve the effect of increasing the likelihood of cancer
US20120015050A1Inactive Publication Date: 2012-01-19MYRIAD GENETICS +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MYRIAD GENETICS
Publication Date
2012-01-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is claims priority to U.S. Provisional Patent Application Ser. No. 61 / 356,501 filed Jun. 18, 2010, the entire contents of which are hereby incorporated by reference.BACKGROUND

[0002] 1. Technical Field

[0003] This document relates to methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, this document provides methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature. This document also provides materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen.

[0004] 2. Background Information

[0005] Cancer is a serious public health problem, with 562,340 people in the United States of America dying of cancer in 200...

Claims

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