Nutritional or therapeutic compositions to increase bodily glutathione levels

a technology of bodily glutathione and composition, applied in the field of nutritional or therapeutic composition, can solve the problems of not being synthesized intracellularly, unable to absorb individual cells as such, and unable to achieve the effect of enhancing the immune activity of a mammal, increasing the production of glutathione, and increasing the formation of glutathion

Inactive Publication Date: 2012-02-02
CRUM ALBERT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is known that insufficient levels of glutathione may result in the onset of numerous diseases.
Even if some of the tripeptide gets through the gastrointestinal wall intact, it is questionable whether it can be absorbed as such into the individual cell, rather than being synthesized intracellularly.

Method used

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  • Nutritional or therapeutic compositions to increase bodily glutathione levels

Examples

Experimental program
Comparison scheme
Effect test

example 1

Tablet

[0050]

Ingredients:89mgcystine75mgglycine147mgglutamic acid22.5μgpolyvinylpynolidone61.25mglactose4.5mlalcohol SD3A-200 proof9mgstearic acid42.3mgcorn starch10μgselenium methionine

[0051]Blend the cystine, glycine, glutamic acid, polyvinylpyrolidone and lactose together and pass through a 40 mesh screen. Add the alcohol slowly and knead well. Screen the wet mesh through a 4 mesh screen. Dry the granulation at 50 degrees centigrade for 10 hours. Pass the mixture of stearic acid, corn starch and selenium compound through a 60 mesh screen and tumble with the granulation until all the ingredients are well mixed. Compress using a 7 / 16 inch standard concave punch.

example 2

[0052]Tablet

Ingredients:178mgcystine150mgglycine294mgglutamic acid5μgselenium methionine126mglactose78mgpotato starch96mgethyl cellulose54mgstearic acid

[0053]Thoroughly mix the ingredients in a blender, dry, put through a 12 mesh screen and compress into tablet using a 13 / 32 inch concave punch.

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PUM

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Abstract

Nutritional or therapeutic compositions containing glutamic acid, cystine, glycine and a selenium precursor and methods for their utilization to increase glutathione synthesis and thereby enhance the immune system are described.

Description

STATEMENT OF PRIORITY[0001]More than one application for the Reissue of U.S. Pat. No. 6,592,908 has been filed. The reissue applications are the present application, U.S. patent application Ser. No. 11 / 371,804, filed Mar. 9, 2006, and U.S. Ser. No. 11 / 181,001, filed Jul. 13, 2005, and issued as U.S. Pat. RE 39,734 on Jul. 17, 2007.FIELD OF THE INVENTION[0002]This invention relates to nutritional or therapeutic compositions useful for treating mammals to increase their body content of glutathione above a pretreatment level thereby to enhance the immune activity of the treated mammal. More specifically, it relates to compositions containing a selenium compound together with a glutathione precursor which is a mixture of glutamic acid, cystine and glycine.BACKGROUND OF THE INVENTION[0003]Glutathione is a tripeptide and a major reducing agent in the mammalian body. Its chemical structure is:or, more simply[0004]GLU-CYS-GLY[0005]Its chemical name is glutamyl-cysteinyl-glycine.[0006]Like m...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/197A61P37/04A61K31/095A61K31/198A61K33/04A61K45/06
CPCA23L1/304Y10S514/905A23V2002/00A61K9/2018A61K31/095A61K31/197A61K31/198A61K33/04A61K45/06A23L1/3051Y10S514/836A61K2300/00A23V2250/1626A23V2250/06A23L33/16A23L33/175A61P19/02A61P25/28A61P29/00A61P3/00A61P3/02A61P31/18A61P35/00A61P37/00A61P37/02A61P37/04A61P39/06A61P43/00A61P9/10
Inventor CRUM, ALBERT
Owner CRUM ALBERT
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