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X-ray contrast media compositions and methods of using the same to treat, reduce or delay the onset of CNS inflammation and inflammation associated conditions

a technology of contrast media and compositions, applied in the direction of drug compositions, peptide/protein ingredients, biocides, etc., can solve the problems of more achieve the effects of improving the treatment of allergic and nasal inflammatory conditions, relieving not only nasal itch, secretions and sneezing, and improving the treatment of severe allergic and inflammatory reactions

Inactive Publication Date: 2013-03-21
3E THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text discusses how adding zinc and / or removing chelator can help treat allergic symptoms, such as nasal itch and congestion. This is because zinc allows an enzyme (ACE) to break down bradykinin, which can cause more severe allergic reactions if left unbroken. By adding zinc or removing chelator, the compositions can improve treatment of nasal inflammatory conditions. In some cases, the compositions may not need to have chelator removed or zinc added, as both may already be present in the body. Adding or removing these components can allow ACE to function more efficiently and improve treatment of allergic symptoms.

Problems solved by technology

The reason for that is believed to be that if ACE is inhibited, then bradykinin is not broken down efficiently, which results in the bradykinin, along with histamine and nitric oxide potentially causing more severe allergic and inflammatory reactions.

Method used

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  • X-ray contrast media compositions and methods of using the same to treat, reduce or delay the onset of CNS inflammation and inflammation associated conditions
  • X-ray contrast media compositions and methods of using the same to treat, reduce or delay the onset of CNS inflammation and inflammation associated conditions
  • X-ray contrast media compositions and methods of using the same to treat, reduce or delay the onset of CNS inflammation and inflammation associated conditions

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0140]The patient suffers from allergic rhinitis. He is prescribed a topical composition comprising an X-ray contrast media that is free of EDTA and Ca-Na EDTA. He applies the composition to the nasal mucosa. The composition comprises CM in a concentration of 150 Mg I / ml to 350 Mg of I / mL. Follow up reveals that the administration of the composition improves the allergic condition.

example 2

[0141]The patient suffers from allergic rhinitis. He is prescribed a topical composition comprising an X-ray contrast media that includes EDTA or Ca-Na EDTA and also a sufficient amount of zinc to allow zinc to act as an ACE enzyme. The composition comprises CM in a concentration of 150 Mg I / mL to 350 Mg I / mL. The composition also includes zinc in a concentration of 0.0004 M to 0.001 M. The patient applies the composition to the nasal mucosa. Follow up reveals that the administration of the composition improves the allergic condition.

example 3

[0142]The patient suffers from allergic conjunctivitis. She is prescribed a composition comprising an X-ray contrast media that is free of EDTA and Ca-EDTA and the composition is suitable for use in the eye. She applies the composition topically to the eye as a drop or gel formulation. The composition comprises CM in a concentration of 150 Mg I / mL to 350 Mg I / mL. Follow up reveals that the administration of the composition improves the allergic condition.

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Abstract

Embodiments disclosed herein relate to improved X-ray contrast media compositions and methods of using the same for treating symptoms related to allergic reactions, inflammatory conditions, symptoms of the common cold and certain cancers.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation-in-part of and claims priority to U.S. application Ser. No. 13 / 237,055, filed on Sep. 20, 2011, entitled IMPROVED X-RAY CONTRAST MEDIA COMPOSITIONS AND METHODS OF USING THE SAME, which is incorporated herein by reference in its entirety.BACKGROUND[0002]1. Field[0003]Embodiments of the technology relate to improved compositions comprising X-ray contrast media (CM) and methods of using the same. Some embodiments of the technology relate to methods to treat central nervous system (CNS) inflammation and / or to treat, reduce or delay the onset of conditions associated with CNS inflammation such as Alzheimer's disease, multiple sclerosis (MS), Parkinson's disease, neurotropic viral infections, stroke, paraneoplastic disorders, traumatic brain injury, and other CNS diseases that are associated with mast cell aggregation and / or inflammation. The methods can utilize the improved compositions described herein as we...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K31/7008A61P25/16A61P25/00A61P25/28A61K31/196A61K33/30
CPCA61K31/167A61K31/196A61K31/7008A61K33/30A61K45/06A61K2300/00A61P25/00A61P25/16A61P25/28
Inventor LASSER, ELLIOTT C.
Owner 3E THERAPEUTICS
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