Treatment of cancer/inhibition of metastasis

a technology of metastasis and cancer, applied in the field of cancer treatment, can solve the problems that patients' doses of these or any other drugs, which would have the effect of completely blocking vgsc currents in cardiac tissue, and would be fatal to patients, and achieve the effect of reducing the number of cells
US20130203764A1Inactive Publication Date: 2013-08-08DJAMGOZ MUSTAFA B A
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
DJAMGOZ MUSTAFA B A
Publication Date
2013-08-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

Substances and methods are disclosed for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part. Inhibition of metastatic cell behaviours such as detachability, lateral motility, transverse migration and invasiveness is demonstrated using the known drugs ranolazine and riluzole.
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Description

BACKGROUND

[0001] This invention relates to the treatment of cancer, and is particularly, but not exclusively, concerned with the treatment of metastatic cancer, such as breast or prostate cancer.

[0002] Progression of metastatic cancer, such as breast and prostate cancer, is generally considered as comprising five phases, as follows:

[0003] 1. Genesis, namely the initial transformation of a normal cell into a cancer cell.

[0004] 2. Proliferation, namely increase in the number of cancer cells to form a primary tumour of increasing size.

[0005] 3. Switching, during the genesis or proliferation phase, from a condition in which the cancer cells have no potential for metastatic behaviour to a condition in which they do.

[0006] 4. Detachment of cancer cells from the primary tumour followed by movement of those detached cells into surrounding regions of tissue within the same organ towards the circulation system.

[0007] 5. Metastasis, namely the movement of the detached cells through the circulation (b...

Claims

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