Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound, extract isolated from antrodia camphorate, and method of inhibiting cancer cell growth

a technology of antrodia camphorate and extract, which is applied in the field of compound and extract isolated from antrodia camphorate, can solve the problems of making i>antrodia camphorata /i>growing inside the tree in the wild even rare, and the price of i>antrodia camphorata /i>is very expensive, and achieves the effect of inhibiting cancer cell growth

Inactive Publication Date: 2014-09-25
TSENG HUI LING
View PDF1 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a new compound, called formula I, which is isolated from Antrodia camphorata. This compound has the ability to inhibit cancer cell growth in several types of cancer, such as lung, colon, prostate, liver, and breast cancer. The invention also provides a method for making the compound and an extract of Antrodia camphorate that can also inhibit cancer cell growth. The new compound can be easily prepared by extracting the fructing body or mycelium of Antrodia camphorata with ethanol and then concentrating the extract.

Problems solved by technology

Cinnamoum kanehirai Hay is rarely distributed and being overcut unlawfully, which makes Antrodia camphorata growing inside the tree in the wild became even rare.
The price of Antrodia camphorata is very expensive due to the extremely slow growth rate of natural Antrodia camphorata that only grows between June to October.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound, extract isolated from antrodia camphorate, and method of inhibiting cancer cell growth
  • Compound, extract isolated from antrodia camphorate, and method of inhibiting cancer cell growth
  • Compound, extract isolated from antrodia camphorate, and method of inhibiting cancer cell growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

Antrodia camphorate Extract

[0014]Antrodia camphorata fruiting bodies, mycelium or their mixture were provided (1.0 kg) and then extracted twice with an 10-fold ethanol solution to obtain two ethanol extracts. The ethanol extracts were concentrated to yield 230 g crude extract (LE-E). The crude extract was extracted three times with dichloromethane / water (1:1) to form a dichloromethane layer (LT-E-D, 102.6 g) and a water layer (LT-E-W, 127.4 g). Dichloromethane layer (6.0 g) was loaded to a layered silica gel column with hexane / dichloromethane (1:4), dichloromethane, and methanol / dichloromethane (5:95) to yield four layers, respectively ANCA-E-D-1, ANCA-E-D-2, ANCA-E-D-3, and ANCA-E-D-4.

Anti Tumor Activity of Antrodia camphorata Extract

[0015]Cell proliferation of A549 cell line (lung cancer), CT26 cell line (colon cancer), DU145 cell line (prostate cancer), HepG2 cell line (liver cancer), MDCK cell line (kidney from canine), PC3 cell line (prostate cancer), MDA-MB-231 cell line (brea...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
coloraaaaaaaaaa
blood pressureaaaaaaaaaa
pressureaaaaaaaaaa
Login to View More

Abstract

Disclosed is a compound isolated from Antrodia camphorata, represented by formula I:wherein R1 is a hydrogen atom or an acetyl group; and a method of inhibiting cancer cell growth by using the compound, the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application claims the priority of Taiwanese patent application No. 102109826, filed on Mar. 20, 2013, which is incorporated herewith by reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to a compound and extract isolated from Antrodia camphorata, particularly relates to a method of inhibiting cancer cell growth by using the compound.[0004]2. The Prior Arts[0005]Antrodia camphorata is also called Chang-Zhi, Niu Chang-Zhi, red camphor mushroom and the like, which is a perennial mushroom belonging to the order Aphyllophorales, the family Polyporaceae. It is an endemic species in Taiwan growing on the inner rotten heart wood wall of Cinnamomum kanehirae Hay. Cinnamoum kanehirai Hay is rarely distributed and being overcut unlawfully, which makes Antrodia camphorata growing inside the tree in the wild became even rare. The price of Antrodia camphorata is very expensive due to the extr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): C07C49/577A61K36/07C07C69/02
CPCC07C49/577C07C69/02A61K36/07C07C403/08C07C2601/16A61K31/122A61P35/00
Inventor CHANG, WEN-LIANGYAO, CHEN-WENYEN, I-CHUANTSENG, HUI LINGTSENG, WAN PINGTSENG, TAI LINKUO, YIN YU
Owner TSENG HUI LING
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com