Compound, extract isolated from antrodia camphorate, and method of inhibiting cancer cell growth

Abstract

Disclosed is a compound isolated from Antrodia camphorata, represented by formula I:

wherein R1 is a hydrogen atom or an acetyl group; and a method of inhibiting cancer cell growth by using the compound, the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application claims the priority of Taiwanese patent application No. 102109826, filed on Mar. 20, 2013, which is incorporated herewith by reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to a compound and extract isolated from Antrodia camphorata, particularly relates to a method of inhibiting cancer cell growth by using the compound.[0004]2. The Prior Arts[0005]Antrodia camphorata is also called Chang-Zhi, Niu Chang-Zhi, red camphor mushroom and the like, which is a perennial mushroom belonging to the order Aphyllophorales, the family Polyporaceae. It is an endemic species in Taiwan growing on the inner rotten heart wood wall of Cinnamomum kanehirae Hay. Cinnamoum kanehirai Hay is rarely distributed and being overcut unlawfully, which makes Antrodia camphorata growing inside the tree in the wild became even rare. The price of Antrodia camphorata is very expensive due to the extr...

AI Technical Summary

Benefits of technology

[0011]A further object of the present invention is to provide a method of inhibiting cancer cell growth by using the above compounds; the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.

[0012]A further object of the present invention is to provide an extract of Antrodia camphorate for inhibiting cancer cell growth, extracted by the following steps: extracting a fruiting body, mycelium, or the mixture thereof twice, with an ethanol solution with a ratio of 1:10 to obtain two ethanol extracts, concentrating the ethanol extracts to yield a crude extract, the crude extract being extracted three times with dichloromethane / water (1:1) to form a dichloromethane layer and a water layer, the dichloromethane layer being loaded to a layered silica gel column with hexane / dichloromethane (1:4), dichloromethane, and methanol / dichloromethane (5:95) to yield the extract.

Problems solved by technology

Cinnamoum kanehirai Hay is rarely distributed and being overcut unlawfully, which makes Antrodia camphorata growing inside the tree in the wild became even rare.

The price of Antrodia camphorata is very expensive due to the extremely slow growth rate of natural Antrodia camphorata that only grows between June to October.

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