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Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus

a technology of lubricating pharmaceutical packages and plasma or cvd, applied in the direction of infusion syringes, surgery, other medical devices, etc., can solve the problems of glass pharmaceutical packages or other vessels that are prone to breakage or degradation, glass particulates may enter the drug, glass-forming processes that do not yield the tight dimensional tolerances required, etc., to improve lubrication, improve lubrication, and reduce sliding friction

Inactive Publication Date: 2016-01-21
SI02 MEDICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is about a way to make things slide better by using a layer of lubricant. This can reduce friction between parts that move against each other, making things work more smoothly. It can also help to drain liquids from vessels, making them easier to use. By spreading the lubricant evenly, a smaller amount of it can be used, which reduces the risk of mixing lubricant with other substances in the vessel. This can be important in situations where the contents of the vessel need to be preserved, such as in medical applications.

Problems solved by technology

Glass pharmaceutical packages or other vessels are prone to breakage or degradation during manufacture, filling operations, shipping and use, which means that glass particulates may enter the drug.
Glass-forming processes do not yield the tight dimensional tolerances required for some of the newer auto-injectors and delivery systems.
Glass is also more difficult and expensive to fabricate into syringes than injection molded plastics.

Method used

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  • Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus
  • Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus
  • Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus

Examples

Experimental program
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examples

Protocol for Coating Syringe Barrel Interior with SiOx

[0208]The apparatus and protocol generally as found in U.S. Pat. No. 7,985,188 were used for coating syringe barrel interiors with an SiOx barrier coating or layer, in some cases with minor variations. A similar apparatus and protocol were used for coating vials with an SiOx barrier coating or layer, in some cases with minor variations.

Protocol for Coating Syringe Barrel Interior with Primer Coating or Layer

[0209]Syringe barrels already interior coated with a barrier coating or layer of SiOx, as previously identified, are further interior coated with a primer coating or layer of SiOxCy as previously identified, generally following the protocols of U.S. Pat. No. 7,985,188 for applying the lubricity coating or layer, except with modified conditions in certain instances.

Protocol for Fi (Breakout or Initiation Force) Measurement

[0210]Convenient methods for measuring the breakout or initiation force required to initiate travel of a p...

examples 1-3

[0221]Syringe samples 1-3, employing three different primer coatings or layers, were produced under the following PECVD conditions:[0222]OMCTS—2.5 sccm[0223]Argon gas—7.6 sccm (when used)[0224]Oxygen 0.38 sccm (when used)[0225]Power—3 watts[0226]Power on time—10 seconds

[0227]Syringe 1 had a three-component primer coating or layer employing OMCTS, oxygen, and carrier gas. Syringe 2 had a two component primer coating or layer employing OMCTS and oxygen, but no carrier gas. Syringe 3 had a one-component primer coating or layer (OMCTS only). The primer coatings or layers produced according to these working examples are contemplated to function as protective coatings or layers to increase the shelf life of the vessels, compared to similar vessels provided with a barrier coating or layer but no primer coating or layer.

examples 4-6

[0228][03] HMDSO was used as the precursor in Examples 4-6. The results are shown in Table 1. The coatings produced according to these working examples are contemplated to function as primer coatings or layers, and also as protective coatings or layers to increase the shelf life of the vessels, compared to similar vessels provided with a barrier coating or layer but no primer coating or layer.

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Abstract

A syringe comprising a wall having a generally cylindrical interior surface defining a lumen with a primer coating or layer between 1 and 1000 nm thick of SiOx Cy Hz, in which x is from about 0.5 to about 2.4, y is from about 0.6 to about 3, and z is from about 2 to about 9, on at least a portion of the interior surface, the primer coating or layer having an outside surface facing the interior surface of the barrel and an inside surface facing the lumen. A deposit of fluid lubricant on the inside surface of the primer coating or layer is further provided.

Description

[0001]This application claims the priority of U.S. Provisional Appl. 61 / 771,644, filed Mar. 1, 2013, all of which is incorporated by reference here to provide continuity of disclosure.[0002]U.S. Provisional Ser. No. 61 / 177,984 filed May 13, 2009; 61 / 222,727, filed Jul. 2, 2009; 61 / 213,904, filed Jul. 24, 2009; 61 / 234,505, filed Aug. 17, 2009; 61 / 261,321, filed Nov. 14, 2009; 61 / 263,289, filed Nov. 20, 2009; 61 / 285,813, filed Dec. 11, 2009; 61 / 298,159, filed Jan. 25, 2010; 61 / 299,888, filed Jan. 29, 2010; 61 / 318,197, filed Mar. 26, 2010; 61 / 333,625, filed May 11, 2010; 61 / 413,334, filed Nov. 12, 2010; 61 / 636,377, filed Apr. 20, 2012; 61 / 654,612, filed Jun. 1, 2012; Ser. No. 12 / 779,007, filed May 12, 2010, now U.S. Pat. No. 7,985,188; International Application PCT / US11 / 36097, filed May 11, 2011; and U.S. Ser. No. 61 / 558,885, filed Nov. 11, 2011; are all incorporated here by reference in their entirety.[0003]Also incorporated by reference in their entirety are the following European pa...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M5/31A61L31/10A61L31/14A61M5/315
CPCA61M5/3129A61M5/31513A61M5/31A61L31/10A61L2400/10A61M2005/3104A61M2005/3131A61M2205/0238A61L31/14C23C16/401A61L2420/02A61L31/026A61L31/048A61L31/088A61L31/16A61L2420/08C23C16/50
Inventor JONES, JOSEPH A.WEIKART, CHRISTOPHERMARTIN, STEVEN J.WILLS, MATTHEW
Owner SI02 MEDICAL PRODS
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