Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus

Abstract

A syringe comprising a wall having a generally cylindrical interior surface defining a lumen with a primer coating or layer between 1 and 1000 nm thick of SiOx Cy Hz, in which x is from about 0.5 to about 2.4, y is from about 0.6 to about 3, and z is from about 2 to about 9, on at least a portion of the interior surface, the primer coating or layer having an outside surface facing the interior surface of the barrel and an inside surface facing the lumen. A deposit of fluid lubricant on the inside surface of the primer coating or layer is further provided.

Description

[0001]This application claims the priority of U.S. Provisional Appl. 61 / 771,644, filed Mar. 1, 2013, all of which is incorporated by reference here to provide continuity of disclosure.[0002]U.S. Provisional Ser. No. 61 / 177,984 filed May 13, 2009; 61 / 222,727, filed Jul. 2, 2009; 61 / 213,904, filed Jul. 24, 2009; 61 / 234,505, filed Aug. 17, 2009; 61 / 261,321, filed Nov. 14, 2009; 61 / 263,289, filed Nov. 20, 2009; 61 / 285,813, filed Dec. 11, 2009; 61 / 298,159, filed Jan. 25, 2010; 61 / 299,888, filed Jan. 29, 2010; 61 / 318,197, filed Mar. 26, 2010; 61 / 333,625, filed May 11, 2010; 61 / 413,334, filed Nov. 12, 2010; 61 / 636,377, filed Apr. 20, 2012; 61 / 654,612, filed Jun. 1, 2012; Ser. No. 12 / 779,007, filed May 12, 2010, now U.S. Pat. No. 7,985,188; International Application PCT / US11 / 36097, filed May 11, 2011; and U.S. Ser. No. 61 / 558,885, filed Nov. 11, 2011; are all incorporated here by reference in their entirety.[0003]Also incorporated by reference in their entirety are the following European pa...

AI Technical Summary

Benefits of technology

[0015]The primer coating or layer improves the lubrication between the relatively sliding parts. More evenly distributed lubricant might be a factor in lowering the sliding friction and making the sliding friction more uniform. As another potential result, in a medical vessel coated on the interior wall with the primer coating or layer and a deposit of lubricant, the more evenly distributed lubricant can improve draining of the vessel. As a third potential result, the more evenly distributed lubricant can be used in a smaller quantity to obtain the same technical effect or advantage, thus potentially reducing the amount of lubricant available to mix with the contents of the vessel. Some potential examples of the lubricant mixing with the contents of the vessel are mechanical or chemical emulsification of the lubricant and a drug or other contents of the vessel.

[0016]Optionally, the primer coating or layer itself, without a deposit of lubricant, can improve draining of the vessel.

Problems solved by technology

Glass pharmaceutical packages or other vessels are prone to breakage or degradation during manufacture, filling operations, shipping and use, which means that glass particulates may enter the drug.

Glass-forming processes do not yield the tight dimensional tolerances required for some of the newer auto-injectors and delivery systems.

Glass is also more difficult and expensive to fabricate into syringes than injection molded plastics.

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