Biomarkers for assessing HIV

Abstract

The present invention relates to metabolic biomarker sets for assessing HIV. In preferred embodiments, the present invention relates to the use of biomarker sets for screening and / or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and / or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject. In other embodiments, the invention relates to methods for screening and / or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and / or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject, as well as to a kit adapted to carry out the methods. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess HIV. In particular, it becomes possible to screen for and diagnose HIV in a patient with high accuracy and predict early in advance the patient's therapeutic response to antiretroviral therapy.

Description

TECHNICAL FIELD[0001]The present invention relates to new biomarkers for assessing HIV. In particular, the present invention provides new biomarkers for screening and diagnosing HIV in patients, predicting immunologic response to antiretroviral therapy and prognosis of HIV disease progression, and monitoring HIV disease activity. Moreover, the present invention relates to a method for assessing HIV in a mammalian subject, and to a kit for carrying out the method. More particularly, the present invention is directed to new diagnostic and predictive biomarkers able to identify patients at higher risk to develop incomplete restoration of immune system after antiretroviral treatment as well as rapid progressors patients.BACKGROUND ART[0002]Metabolomics[0003]Metabolomics is a comprehensive quantitative measurement of low molecular weight compounds covering systematically the key metabolites, which represent the whole range of pathways of intermediary metabolism. The capability to analyze...

AI Technical Summary

Problems solved by technology

Therefore they cannot necessarily predict drug effects, toxicological response or disease states at the phenotype level unless functional validation is added.

As the illness progresses, it interferes more and more with the immune system, making the person much more likely to get infections, including opportunistic infections and tumors that do not usually affect people who have working immune systems.

There is currently no cure or effective HIV vaccine.

However, it is becoming increasingly evident that the CD4 count and viral load do not provide a complete picture of the underlying state of the immune system for HIV patients.

However, they are still far from clinical use.

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