The invention discloses a cultivation method of selenium-enriched asparagus, and belongs to the technical field of cultivation of traditional Chinese medicinal material. The cultivation method of theselenium-enriched asparagus comprises the following steps: step one, planting holes are dug, wherein the planting holes are dug according to a row spacing of 40-48 cm and a plant spacing of 22-28 cm;step two, transplanting is conducted, wherein 800-1000 g of miscellaneous manure are applied into the planting holes, a seedling is transplanted and soil covers the planting holes and is compacted; step three, weed control is performed, wherein three-time weed controls are performed each year, the first time is in March to April, the second time is in June to July, the third time is in September to October, the weed control should be 8-9 cm beneath the soil; step four, topdressing is performed, wherein compound fertilizer aqueous solution is sprayed once every three months after transplanting,and the compound fertilizer is composed of carbomite, potassium dihydrogen phosphate, potassium chloride, selenite, potassium naphthalene acetate, carbendazim and sodium pentachlorophenate. Comparedwith the current planting method, the planted asparagus has high selenium content, is more in line with human needs, as a traditional chinese medicinal material, the asparagus not only can treat related diseases, but also can supplement selenium to achieve the effects of regulating immunity, resisting cell mutations and avoiding cancer occurrence.