Formulations of vancomycin
a vancomycin and formula technology, applied in the field of glycopeptide antibiotics, can solve the problems of premature degradation of vancomycin and unsuitable long-term storage in liquid form, and achieve the effect of improving long-term stability
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[0084]The following examples serve to provide further appreciation of the invention but are not meant in any way to restrict the effective scope of the invention.
examples 1-4 (
100mg / mL Vancomycin)
Example 1 (75% (v / v) 1M Lactic Acid Solution and 25% (v / v) PG):
[0085]A lactic acid solution was prepared by dissolving 7.68 g of an 88% lactic acid solution in 40 mL water for injection. The pH was then adjusted to 5.5 with a 2N sodium hydroxide solution. A 75:25 lactic acid:PG solution was prepared by adding 25 mL of PG to the above lactic acid solution, and the volume was made up to 100 mL with water for injection. 10 g of vancomycin HCl was then added to 75 ml of the 75:25 lactic acid:PG solution and the volume was made up to 100 mL with the 75:25 lactic acid:PG solution to yield a vancomycin concentration of 100 mg / mL. The sample was mixed well. 2N sodium hydroxide solution was added to the sample to bring the pH to 5.5.
example 2 (
50% (v / v) 1M Lactic Acid Solution and 50% (v / v) PG):
[0086]A lactic acid solution was prepared by dissolving 5.12 g of an 88% lactic acid solution in 40 mL water for injection. The pH was then adjusted to 5.5 with a 2N sodium hydroxide solution. A 50:50 lactic acid:PG solution was prepared by adding 50 mL of PG to the above lactic acid solution, and the volume was made up to 100 mL with water for injection. 10 g of vancomycin
[0087]HCl was then added to 75 mL of the 50:50 lactic acid:PG solution and the volume was made up to 100 mL with the 50:50 lactic acid:PG solution to yield a vancomycin concentration of 100 mg / mL. The sample was mixed well. 2N sodium hydroxide solution was added to the sample to bring the pH to 5.5.
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