Systems and methods for the diagnosis and treatment of neurological disorders

a neurodegenerative disorder and systemic technology, applied in the field of neurodevelopmental and neurodegenerative disorders, can solve the problems of ineffective current methods addressing these two objectives, and achieve the effect of high functioning

Inactive Publication Date: 2017-11-30
RUTGERS THE STATE UNIV +1
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Problems solved by technology

Current methods are ineffective at addressing these two objectives.

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  • Systems and methods for the diagnosis and treatment of neurological disorders
  • Systems and methods for the diagnosis and treatment of neurological disorders
  • Systems and methods for the diagnosis and treatment of neurological disorders

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[0144]A critical need in autism research and its treatments is to find an efficient quantitative way to categorize the disorder. In a given cohort of affected people there is high probability that not two individuals are alike, even when their ADOS (Lord et al. (2000) J. Autism Dev. Disord., 30:205-223) scores may classify them similarly. One may find, for example, that two children who are classified as medium functioning show surprising differences in their individual capabilities and predispositions that set them apart.

[0145]The active field of computational neuroscience and in particular the subfields of sensory-motor physiology and motor control may provide this bridge because behaviors that are verbally described by clinicians can be objectively quantifiable. Behaviors are composed of many movements with different levels of intent (Tones, E. B. (2012) Neurocase, 1:1-16; Tones, E. B. (2011) Exp Brain Res., 215:269-283). They flow as a continuous stream of motions that occur at ...

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Abstract

Systems and methods for data compression which facilitate the diagnosis and treatment of neurodevelopmental and neurodegenerative disorders. The methods comprise performing the following operations by a computing device: generating Normalized Data ("ND") from Original Data ("OD") that defines a Normalized Waveform ("NW") that is unitless and scaled from zero to one; processing ND to extract Micro-Movement Data ("MMD") defining a Micro-Movement Waveform ("MMW") comprising a plurality of MMD points; and generating compressed data comprising a stochastic signature of MMW. Each MMD point determined based on a value of a peak of NW and a value representing an average of all data point values between a first valley of NW immediately preceding the peak and a second valley of NW immediately following the peak. The stochastic signature is defined by empirically estimated values of at least one parameter representing a Probability Distribution Function ("PDF") of a continuous family of PDFs.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Patent Ser. No. 62 / 198,930 filed on Jul. 30, 2015, and is a continuation-in-part of U.S. patent application Ser. No. 14 / 354,796 filed Apr. 28, 2014, which is a U.S. National Phase of International Patent Application Serial No. PCT / US2012 / 064805 filed Nov. 13, 2012, which claims priority under 35 U.S.C. §119(e) to U.S. Patent Ser. No. 61 / 648,359 filed on May 17, 2012, U.S. Patent Ser. No. 61 / 581,953 filed on Dec. 30, 2011, and U.S. Patent Ser. No. 61 / 558,957 filed on Nov. 11, 2011. The content of the above applications are incorporated by reference in their entirety.GOVERNMENT RIGHTS[0002]The invention was made with Government support under Grant No. 0941587 awarded by the National Science Foundation. The Government has certain rights in the invention.FIELD OF THE INVENTION[0003]This document relates generally to neurodevelopmental and neurodegenerative disorders (e.g., autism spectrum disorders). M...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G06F19/00A61B5/00G16H20/70G16H50/20H04L29/06
CPCG06F19/325A61B5/40G06F19/345H04L63/0428G06F19/322A61B5/0015A61B5/11A61B5/4076A61B5/4082A61B5/7264A61B5/168A61B5/4088A61B5/4094A61B5/162A61B5/4848G16H10/60G16H50/20G16H20/70G16Z99/00A61B5/1124A61B5/1125A61B5/1128A61B5/1104A61B5/7278A61B5/1114A61B5/7275G16H40/20
Inventor TORRES, ELIZABETH B.JOSE-VALENZUELA, JORGE
Owner RUTGERS THE STATE UNIV
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