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Active formulation for use in feed products

Inactive Publication Date: 2018-03-08
PURAC BIOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The solution ensures a stable, bioactive, and free-flowing powder that maintains flow properties and bioavailability, effectively addressing the consumption and stability issues of hydroxyl-acid esters in animal feed.

Problems solved by technology

A problem with these compounds, however, is to ensure that they are actually consumed by the animal in sufficient amounts.

Method used

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  • Active formulation for use in feed products
  • Active formulation for use in feed products

Examples

Experimental program
Comparison scheme
Effect test

example 1

sed on Diatomaceous Earth Carrier

[0071]The starting material was 4.65 kg of calcined diatomaceous earth (Absomol AB-10 KF provided by Damolin s.a), the particle size distribution of which is given in the following table:

DDDDD(0.1)(0.5)(0.9)[3, 2][4, 3]SpanSample Nameμmμmμmμmμm(—)Absomol AB10KF2784717644324991.03

[0072]4.65 kg of this material was heated to a temperature of 100° C. and brought to a vacuum pressure of 200 mbara. Then it was sprayed with 3.1 kg of PURAMIX 100 melt, which is a mixture of 70% wt sodium lauroyl lactylate and 30% wt sodium myristoyl lactylate at a nozzle pressure of 5 bar, a temperature of the liquid of 135 C and a spay rate of 7.5 kg / minute through a pressure nozzle. The end product had a temperature of 90° C. and a loading of 40 wt. %. It was a free-flowing powder (Hausner ratio of 1.04) with a non-sticky (tack-free) surface. The final product showed the same particle size characteristics and flowability characteristics as the initial carrier, indicating ...

example 2

sed on Vermiculite Carrier

[0073]The starting material was Vermiculite Nr.0 exfoliated (provided by KRAMER PROGETHA), the particle size distribution of which is given in the following table:

DDDDD(0.1)(0.5)(0.9)[3, 2][4, 3]SpanSample Nameμmμmμmμmμm(—)Vermiculite2965259554555851.25expanded nr.0

[0074]1.3 kg of starting material was heated to a temperature of 100° C. and brought to a vacuum pressure of 200 mbara. Then it was sprayed with 1.95 kg of PURAMIX 100 melt, which is a mixture of 70% wt sodium lauroyl lactylate and 30% wt sodium myristoyl lactylate at a nozzle pressure of 5 bar, a temperature of the liquid of 135 C and a spay rate of 2.6 kg / minute through a pressure nozzle. The end product had a temperature of 95° C. and a loading of 60 wt. %. It was a free-flowing powder (Hausner ratio of 1.07) with a non-sticky (tack-free) surface. The final product showed the same particle size characteristics and flowability characteristics as the initial carrier, indicating that the liquid h...

example 3

sed on Sepiolite Carrier

[0075]The starting material was Sepiolite (Provided by Provimi B.V Netherlands), the particle size distribution of which is given in the following table:

DDDDD(0.1)(0.5)(0.9)[3, 2][4, 3]SpanSample Nameμmμmμmμmμm(—)Sepiolite1783656512053891.30

[0076]7.3 kg of starting material was heated to a temperature of 100° C. and brought to a vacuum pressure of 200 mbara. Then it was sprayed with 3.2 kg of PURAMIX 100 melt, which is a mixture of 70% wt sodium lauroyl lactylate and 30% wt sodium myristoyl lactylate at a nozzle pressure of 5 bar, a temperature of the liquid of 135 C and a spay rate of 2.6 kg / minute through a pressure nozzle. The end product had a temperature of 80° C. and a loading of 30 wt. %. It was a free-flowing powder (Hausner ratio of 1.03) with a non-sticky (tack-free) surface. The final product showed the similar size characteristics and flowability characteristics as the initial carrier, indicating that the liquid has been absorbed by the particles....

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Abstract

Invention pertains to a free-flowing particulate powder including 2-90 wt. % of an active compound on a carrier, wherein the carrier has a D(v,0.1) of at least 100 microns, with the active compound being selected from lactylate in accordance with formula (1), Formula (1): R2-COO—[—CH(CH3)-COO]n-R1 or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof, a glycolylate of formula (2), Formula (2): R2-COO—[—CH2-COO]n-R1 or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof a lactate ester of formula (3), Formula (3): HO—CH(CH3)-COO—R2 and / or a glycolic acid ester of formula (4), Formula (4): HO—CH2-COO—R2 wherein in the above formulae R1 is selected from H, n stands for an integer with a value of 1-10, and R2 stands for a C1-C35 alkyl or alkenyl chain which may be branched or unbranched. The powder allows easy provision of the active compound to feed compositions.

Description

[0001]This is a Division of application Ser. No. 14 / 131,216 filed Feb. 12, 2014, which in turn is a National Stage Entry of PCT / EP2012 / 062926 filed on Jul. 3, 2012, which claims the benefit of U.S. Provisional Application No. 61 / 505,810 filed Jul. 8, 2011 and European Patent No. 11173177.4 filed on Jul. 8, 2011. The disclosure of the prior applications is hereby incorporated by reference herein in its entiretyBACKGROUND[0002]It is known in the art that hydroxyl-acid esters such as lactylates and related compounds may be attractive to include in feed products. For example, WO 2009 / 092787 describes the use of these compounds in the treatment or prevention of intestinal infections in animals, and to increase the animal growth rate.[0003]A problem with these compounds, however, is to ensure that they are actually consumed by the animal in sufficient amounts. This requires that the product is mixed homogeneous through the animal feed, and that the mixture stays homogeneous upon transport...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/23A23K50/75A23K20/24A23K20/158A61K9/16A23K40/10A23K20/105
CPCA23K50/75A23K20/24A23K20/158A61K9/167A23K40/10A61K31/23A23K20/105A61P1/00A61P3/00A61P31/04A61P43/00A23K20/10
Inventor KOK, SYMONEVOGIATZIS, NIKOLAOS
Owner PURAC BIOCHEM