Compositions and Methods for Treating Pain with Wogonin

Pending Publication Date: 2021-02-25
BRIGHAM YOUNG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a method for treating arthritis in humans by applying a composition containing wogonin to the affected joint. This can reduce inflammation and promote healing, ultimately reducing the likelihood of joint damage. The treatment can also lead to fewer cyst-like lesions, lower OARSI scores, and inhibition of cartilage degradation.

Problems solved by technology

Musculoskeletal pain and arthritic pain is a major problem for people around the world.
Particularly problematic is osteoarthritis (OA), which is a chronic disease affecting over 27 million people in the United States (U.S.) among many others.
As part of the inflammatory pathway driving OA progression, matrix degrading proteases HtrA1 and MMP-13 are secreted by chondrocytes into the pericellular and extracellular matrix, resulting in reduced matrix integrity and function.
To date, however, there are no successful treatment options that can reverse the disease etiology associated with OA.
In addition, there are limited options for the safe and effective treatment of conditions stemming from musculoskeletal pain.

Method used

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  • Compositions and Methods for Treating Pain with Wogonin
  • Compositions and Methods for Treating Pain with Wogonin
  • Compositions and Methods for Treating Pain with Wogonin

Examples

Experimental program
Comparison scheme
Effect test

example 1

reatment of a Mouse Model of Osteoarthritis Formulated as a Cream

[0083]The use of wogonin for the treatment of osteoarthritic (OA) pain was investigated. Specifically, the benefit of using small doses of wogonin applied topically in a cream with penetration enhancers was investigated. The cream formulation shown in Table 2 was used in this study. An additional exemplary cream formulation for administering wogonin is provided in Table 3.

[0084]An OA mouse model was used to determine the efficacy of wogonin treatment. OA-like disease was induced by surgical destabilization of the medial meniscal ligament (DMM) of laboratory mice. Repair of the knee was assessed using the Modified Mankin Score which is widely accepted as the way to objectively compare OA progression by histological evaluation of a knee joint (See Larkin D J et al., Frontiers in physiology. 2013; 4:121 and Mankin H J. The New England journal of medicine. 1974; 291(24):1285-92). The mice were housed in activity wheel cage...

example 2

reatment of a Mouse Model of Osteoarthritis Formulated in a Cream or in a Liquid

[0089]A second experiment using small doses of wogonin applied topically either in DMSO or in a cream with penetration enhancers was conducted. The cream formulation provided in Table 1 was used. In this study, OA was induced by DMM surgery. Twenty four hours after surgery treatment was applied to the affected knee. The treatments included 0.00000142 g wogonin in 10 μl DMSO (500 μM wogonin) applied to the skin at the location of patellar tendon (n=5); 10 μl DMSO applied to the skin at the location of patellar tendon (n=5); 0.0000000028 g wogonin (10 μl G2 Cream E / 10 μM wogonin) to the skin at the location of the patellar tendon (n=5). Treatment was applied every third day for 28 days. Immediately after surgery, mice were placed in an activity wheel cage in which wheel use was recorded on a computer. Seven days after starting the experiment, the mice treated receiving either wogonin in DMSO or in a cream ...

example 3

ormulation for the Administration of Wogonin

[0091]An exemplary roll-on formulation for the administration of wogonin is provided in Table 6.

TABLE 6Exemplary Roll-on CompositionIngredientWaterAlcoholCaprylic / Capric TriglyceridePropanediolEthoxydiglycolMentha Piperita (Peppermint) OilDimethiconeCetearyl AlcoholGlyceryl StearatePotassium Olivoyl Hydrolized Oat ProteinCetyl AlcoholXanthan GumPhenoxyethanolCaprylyl GlycolGlyceryl OleateSclerotium GumLecithinEthylhexylglycerinHexylene GlycolPullulanMentholSodium PhytateWogonin

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Abstract

The invention described herein relates to compositions and methods for treating pain with wogonin. In particular, described herein are compositions and methods for treating musculoskeletal pain and arthritis with wogonin.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Patent Application No. 62 / 615,072, filed Jan. 9, 2018, and U.S. Provisional Patent Application No. 62 / 756,188, filed Nov. 6, 2018, the entire contents of each of which are hereby incorporated herein by reference.TECHNICAL FIELD[0002]The invention described herein relates to compositions and methods for treating pain with wogonin. In particular, described herein are compositions and methods for treating musculoskeletal pain and arthritis.BACKGROUND INFORMATION[0003]Musculoskeletal pain and arthritic pain is a major problem for people around the world. Pain stemming from these conditions is associated with aberrant inflammation. Particularly problematic is osteoarthritis (OA), which is a chronic disease affecting over 27 million people in the United States (U.S.) among many others. OA is recognized to be a multifactorial disease associated with risk factors such as obesity, joint-loadi...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/00A61K45/06A61K9/06A61K47/20A61K47/10A61K47/44A61P19/02
CPCA61K31/352A61K9/0014A61K45/06A61P19/02A61K47/20A61K47/10A61K47/44A61K9/06A61P21/00A61K9/0019A61K9/107A61K9/10A61P29/00
Inventor KOOYMAN, DAVID LEE
Owner BRIGHAM YOUNG UNIV
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