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Immunoregulator

a technology of immunomodulator and immune system, applied in the field of immunomodulator, can solve problems such as severe tissue damag

Inactive Publication Date: 2008-04-29
BIOTEMPT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

An autoimmune response may also occur as manifestation of viral or bacterial infection and may result in severe tissue damage, for example destructive hepatitis because of Hepatitis B virus infection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example i

[0072]Introduction

[0073]The immune system has two arms: the non-specific (innate) and specific (adaptive) immune defense, both of which have cellular and humoral components. T and B cells account for the antigen-specific cellular and humoral (antibodies) immune defense. On the other hand, monocytes / macrophages, granulocytes, NK cells, mast cells and likely also gd T cells are the cellular components of the innate immune system, while complement, acute phase proteins, lysozyme and mannose-binding lectin (MBL) are major humoral components of the innate immune system. The adaptive system has been studied most because of its specificity and lasting effectiveness in eliminating infections. The innate system is thought to play a critical role in the most fundamental immune challenge in mammals: viviparity.

[0074]The innate system instigates an immune response by processing and presenting antigen in association with major histocompatibility complex (MHC) class I and II molecules to lymphocy...

example ii

[0121]Materials and Methods

[0122]Gel permeation: We fractionated commercial hCG preparation (c-hCG, Pregnyl, Organon, Oss, The Netherlands) as follows: we used Shimadzu HPLC system equipped with Alltech macrosphere size exclusion (GPC) 60 Å column (4.6 mm ID×250 mm L) in 50 mM ammonium bicarbonate buffer. The separation range for this column was 28,000-250 Dalton. Sample (20,000 IU hCG / ml) load volume was 10-50 ml. The flow rate was 0.3 ml / min for 25 minutes. External molecular weight standards were also employed to calibrate the column elution positions. The markers used were: aprotinin (6,500 Da), cytochrome C (12,400) and carbonic anhydrase (29,000). In addition, the concentrated urine (see urine purification) obtained from Pelicon system was filtered through 0.45 mm filter and 40,000 IU c-hCG (Pregnyl) dissolved in 50 mM ammonium bicarbonate were analysed on Shimadzu HPLC system equipped with Superdex G25 (30 mm ID×990 mm L) desalted column in 50 mM ammonium bicarbonate buffer s...

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Abstract

The invention relates to the field of immunology, more specifically to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease or inflammatory disease. The invention provides among others an immunoregulator (NMPF), use of an NMPF in preparing a pharmaceutical composition for treating an immune-mediated disorder, a pharmaceutical composition and a method for treating an immune-mediated disorder.

Description

RELATED APPLICATION[0001]This application is a continuation of co-pending International Application No. PCT / NL01 / 00259, (International Publication No. WO 01 / 72831 A2) filed Mar. 3, 2001, designating the United States of America, the contents of which are incorporated by this reference.FIELD OF THE INVENTION[0002]The invention relates to the field of immunology, more specifically to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease or inflammatory disease.BACKGROUND[0003]The immune system produces cytokines and other humoral factors to protect the host when threatened by inflammatory agents, microbial invasion, or injury. In most cases this complex defence network successfully restores normal homeostasis, but at other times the immunological mediators may actually prove deleterious to the host. Some examples of immune disease and immune system-mediated injury have been extensively investigated including anaphylactic shock, ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K38/04C07K5/00G01N33/68A61K38/00A61K38/24A61K38/27A61K39/395A61P3/10A61P9/00A61P9/10A61P11/06A61P15/06A61P19/02A61P25/00A61P25/28A61P29/00A61P31/04A61P31/12A61P31/18A61P31/22A61P33/00A61P35/00A61P37/02A61P37/06A61P37/08A61P43/00C07K7/04C07K14/59
CPCC07K14/59A61K38/00A61P11/00A61P11/06A61P15/00A61P15/06A61P19/00A61P19/02A61P25/00A61P25/28A61P29/00A61P3/00A61P3/10A61P31/00A61P31/04A61P31/12A61P31/18A61P31/22A61P33/00A61P35/00A61P37/00A61P37/02A61P37/06A61P37/08A61P43/00A61P9/00A61P9/10A61K38/24
Inventor KHAN, NISAR A.BENNER, ROBBERT
Owner BIOTEMPT
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