Compositions for bowel cleansing and use thereof

Abstract

The present invention relates to a dry composition for reconstitution in water comprising polyethylene glycol (PEG), optionally sodium sulphate, citric acid, sodium citrate, sodium chloride, potassium chloride, simethicone, effective for bowel cleansing, in particular of colon, prior to diagnostic, surgical or therapeutical procedures, in particular colonoscopy.

Description

TECHNICAL FIELD OF THE INVENTION[0001]The present invention relates to a composition useful for bowel cleansing prior to carry out diagnostic, surgical or therapeutic procedures in the bowel, in particular in the colon (such as for example colonoscopy, radiology and colon surgery).BACKGROUND OF THE INVENTION[0002]The preparation of bowel, in particular of colon, prior to diagnostic, surgical or therapeutical procedures, for example colonoscopy, is a crucial prerequisite for a successful procedure.[0003]In the past, the bowel preparation was carried out with high volume solutions (7-12 liters) with or without non-absorbable sugars (such as mannitol) which had respectively the inconvenience of causing water retention and promoting the production of potentially dangerous high quantity of gas.[0004]In other cases, hyperosmotic saline laxatives were used, which had a drastic cathartic effect on bowel with the risk, for example, of dehydration, electrolyte imbalances, cardiovascular and r...

AI Technical Summary

Benefits of technology

The present invention relates to a dry composition for reconstitution in water that includes polyethylene glycol (PEG), optionally sodium sulphate, citric acid, sodium citrate, sodium chloride, potassium chloride, and simethicone. The invention also includes a use of this dry composition for making a bowel cleansing preparation. This invention provides a more effective and easier way to prepare a bowel cleansing preparation without the need for a laxative. The aqueous solution obtained by reconstitution in water of the dry composition provides consistent and effective cleaning without causing any discomfort or inconvenience to the user.

Problems solved by technology

Furthermore, those formulations are frequently characterized by a poor palatability.

Nevertheless, the quality of the colon preparation is still reported as poor or unacceptable in about 15-20% of the colonoscopies.

This is probably due to the fact that 10 to 15% of patients do not complete the preparation because of poor palatability and / or large volume of the administered solution.

Inadequate cleansing of the colon may lead to: a) increased risk of false negative (missed diagnosis), b) more frequent complications, c) longer procedures with increased discomfort for the patient, d) incompleteness of the procedure with the need to repeat the investigation.