The invention discloses a freshly-squeezed paulownia flower spray-dried granular decoction piece and a preparation technology thereof. The preparation technology comprises the following steps: after the paulownia flowers are harvested, picking qualified paulownia flowers, washing selected paulownia flowers, squeezing the fresh paulownia flowers, filtering the juice, adding water into the residues, filtering, squeezing; merging the juice, carrying out reduced pressured concentration, spray-drying the liquid, collecting the spray-drying product, grinding the collected solids, mixing the grinded solids with primarily-squeezed juice, carrying out granulation, finishing, and packaging the granules into vacuum bags. The provided preparation method maximally preserves the polar and non-polar effective components in paulownia flowers. The decoction piece has good fluidity, and is convenient for transportation, storage, and blending, the quality is controllable, and the curative effect is reliable. The preparation technology has an important meaning for ensuring the clinical curative effect of traditional Chinese medicine. The provided decoction piece can generate prominent social benefits and economic benefits.