The invention discloses a high-salt cyanide-containing wastewater treatment process and system, which are mainly used for performing the treatment of neutralization , cyanogen removal, ammonia nitrogen removal, COD (Chemical Oxygen Demand) removal and the like on metal zirconium production wastewater. The process involves the combined processes of coagulative precipitation, ammonia stripping, electrochemical/chemical oxidization, biochemical reaction and the like. The device comprises treatment facilities such as a coagulative precipitation device, an ammonia stripping device, an electrolysis cyanide breaking device, a chemical cyanide removing device, an electro-catalysis oxidizing device, a chemical oxidizing device, a water distribution hydrolytic tank, an A/O (Anoxic/Oxic) biochemical tank, and a secondary precipitation tank. By adopting the high-salt cyanide-containing wastewater treatment process and system, the problem related to treatment of high-salt, high-cyanide, high-COD and high-ammonia and nitrogen wastewater is solved. The wastewater treatment process has a long flow, but the features of different processes are brought into full play; particular pollutants are removed specifically, and the running cost is relatively low; moreover, pollutants such as cyanogen, COD and ammonia nitrogen are removed fundamentally, and a stable running effect is achieved.